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Clinical Chemistry 45: 2039-2040, 1999;
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(Clinical Chemistry. 1999;45:2039-2040.)
© 1999 American Association for Clinical Chemistry, Inc.

Letters

Evidence of Temperature-dependent Interference in an Immunonephelometric Assay by Monoclonal IgM

Robert Granouillet1, Françoise Rascle2, Christine Bonneau2, Annette Chamson2, Jacques Frey1,a and Christian Perier1

1 Laboratoire de Biochimie, Hôpital Nord, and,
2 Laboratoire de Biochimie, Hôpital Bellevue, CHU-Hôpitaux de Saint-Etienne, 42055 Saint-Etienne Cedex 2, France
a Address correspondence to this author at: Laboratoire de Biochimie, Faculté de Médecine, 15 Rue Ambroise Paré, 42023 Saint-Etienne Cedex 2, France. Fax 33-4-77-42-14-89; e-mail frey@univ-st-etienne.fr.


To the Editor:

Interference by monoclonal IgM has been described in the immunonephelometric assays of C-reactive protein, antistreptolysin O, ferritin, and complement C4 (1)(2)(3)(4)(5)(6). This report describes the interference by monoclonal IgM (IgM{kappa}) in the immunonephelometric assays of apolipoproteins A-I and B, haptoglobin, and immunoglobulins A and G.

The patient, a man 54 years of age, was admitted to a cardiac care unit with angina. His total plasma protein was 110 g/L, his serum cholesterol was 3.3 mmol/L, his apolipoprotein A-I was 1.5 g/L, and his apolipoprotein B was 2 . . . [Full Text of this Article]


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