Clinical Chemistry
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Clinical Chemistry 45: 315-316, 1999;
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(Clinical Chemistry. 1999;45:315-316.)
© 1999 American Association for Clinical Chemistry, Inc.

Letters

Interlaboratory Variability for Total Homocysteine Analysis in Plasma

Stephen C. Eliason1, Detlef Ritter1,2,a, Hyung D. Chung1,2 and Michael Creer1

1 Department of Pathology, Saint Louis University, School of Medicine, St. Louis, MO 63104,
2 Pathology and, Laboratory Medical Service, John Cochran Veterans Affairs, Medical Center, St. Louis, MO 63106
a Address correspondence to this author at: Clinical Laboratories, 3635 Vista at Grand, St. Louis, MO 63110-0250. Fax 314-289-7073; e-mail ritterdg@slu.edu.


To the Editor:

Total plasma homocysteine consists of free homocysteine and homocysteine that is complexed with itself or with other amino acids or proteins. Free homocysteine has been measured previously as part of a biochemical screen for inherited metabolic disorders. More recently, increased total plasma homocysteine has been suggested as an independent risk factor for atherosclerotic coronary artery disease [reviewed in Ref. (1)]. In addition, increased total homocysteine is associated with a poor prognosis in patients with angiographically demonstrated coronary artery disease(2). These studies have prompted clinicians to include total homocysteine analysis as part of the risk assessment profile of patients with premature coronary artery disease. . . . [Full Text of this Article]


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The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
N. L. Duarte, X. L. Wang, and D. E. L. Wilcken
Effects of Anticoagulant and Time of Plasma Separation on Measurement of Homocysteine
Clin. Chem., April 1, 2002; 48(4): 665 - 668.
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