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Clinical Chemistry 45: 1312, 1999;
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(Clinical Chemistry. 1999;45:1312.)
© 1999 American Association for Clinical Chemistry, Inc.

Letters

The Plasma Homocysteine/Creatinine Ratio Can Be Used to Study the Implication of (C677T) MTHFR Genetic Variants in Homocysteine Homeostasis

Maryvonne Cuera

a Author for correspondence. Fax 33-1-40258821; e-mail labo.bioa@bch.ap-hop-paris.fr.

Sandrine Barrot, Françoise Jaureguy, Dieudonné Manéné, Geneviève Durand and Gisèle Le Moël

Biochemical A Laboratory, 46 rue Huchard, Bichat-Claude Bernard Hospital, 75877 Paris cédex 18, France


To the Editor:

As discussed in a recent review (1), it is accepted that the determinants of total plasma homocysteine are numerous. The usual factors involved are age, sex, nutritional status, renal function, and genetic status. In this study, we sought to discriminate the influence of the C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene on plasma total homocysteine. We studied a healthy French population (n = 78) with serum folate (9.4 ± 3.2 µg/L, mean ± SD) and plasma creatinine (79.7 ± 12.8 µmol/L) values within the references intervals and of known age, sex, and MTHFR genetic status (41 women, ages 38.2 ± 9.9 years, . . . [Full Text of this Article]


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