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Clinical Chemistry 45: 1315, 1999;
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(Clinical Chemistry. 1999;45:1315.)
© 1999 American Association for Clinical Chemistry, Inc.

Letters

Furosemide Interference in Newer Free Thyroxine Assays

Nicos Demetriou Christofides

Research and Development, Ortho-Clinical Diagnostics, Cardiff Laboratories, Whitchurch, Forest Farm Estate, Cardiff CF4 7YT, Wales, UK, Fax 44 1222 526635,


To the Editor:

The Technical Brief by Hawkins (1) refers to the increase in measured serum free thyroxine (FT4) concentrations by furosemide as "interference", and this deserves comment. As discussed previously (2)(3), one can legitimately conclude that an assay is unaffected after the addition of exogenous substances (such as thyroid hormone-binding proteins or binding inhibitors) if the assay measures the total amount of the analyte (such as T4). The situation is, however, different with assays measuring free analyte (e.g., FT4) concentrations. This is because the FT4 concentration (as dictated by the law of mass action) depends on the equilibrium that exists between the protein-bound T4 (PBT4) and the serum binding capacity (sBC, which is . . . [Full Text of this Article]


References

Robert C. Hawkins

Department of Pathology, and Laboratory Medicine, Tan Tock Seng Hospital, Moulmein Rd., Singapore 308433, E-mail Robert_Hawkins@notes.ttsh.gov.sg


To the Editor:




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
J. Penders, T. Fiers, and J. R. Delanghe
Quantitative Evaluation of Urinalysis Test Strips
Clin. Chem., December 1, 2002; 48(12): 2236 - 2241.
[Abstract] [Full Text] [PDF]


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