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Clinical Chemistry 45: 1678-1679, 1999;
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(Clinical Chemistry. 1999;45:1678-1679.)
© 1999 American Association for Clinical Chemistry, Inc.

Oak Ridge Poster Sessions

Highly Miniaturized and Integrated Biosensor for Analysis of Whole Blood Samples

Bernhard P.H. Schaffara, Heinz Kontschieder, Christoph Ritter and Hans Berger

AVL Medical Instruments, Hans List Platz 1, A-8020 Graz, Austria
a author for correspondence: fax 43-316-787-635, e-mail Bernhard.Schaffar@avl.com

Fast point-of-care testing of metabolite concentrations has become more common in critical care analysis (1)(2)(3). We developed an integrated biosensor cassette for the determination of glucose, lactate, and urea in microsamples of undiluted whole blood or plasma. The biosensor cassette requires no maintenance and can be used for 1 week or 500 samples after insertion into an AVL OMNI® blood gas and electrolyte instrument. The linear analytical ranges of these sensors include the physiological ranges and most of the pathological ranges, e.g., glucose up to 40 mmol/L, lactate up to 20 mmol/L, and urea up to 40 mmol/L.

This integrated planar solid state sensor (38 x 20 mm) is produced using thick-film technology, allowing high reproducibility at very competitive manufacturing costs. The sensor cassette consists of 12 electrode spots (each 1.2 mm in diameter); 9 spots are used for glucose and lactate, and 3 are used for urea. The total fill volume of a cassette is 44 µL, including 6 µL for an external maintenance-free reference electrode for the potentiometric urea sensor system. The integrated biosensor is thermostated in . . . [Full Text of this Article]


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Copyright © 1999 by the American Association for Clinical Chemistry.