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New Miniaturized Highly Sensitive Immunoassay Device for Quantitative Measurement of Soluble or Particular Antigen or Antibodies in a Liquid Sample

Stago International, 9 Rue des Frères Chausson, 92600 Asnieres, France
^a author for correspondence

Modern clinical practice requires small, easy-to-use, quantitative, automated near-the-patient test systems. Any new test system must match the clinical needs for faster and cost-effective technological approaches. The TECHNODISK concept addresses many of the key features required for rapid immunoanalysis, i.e., microfluidics, speed, safety, flexibility, and capability for multitest panels.

The system is a flat cylinder cassette named TECHNODISK composed of two plastic parts. The bottom part is a polystyrene plastic mould designed with three concentric areas separated by walls in which holes have been made that allow for the circulation of fluids from the inner area, to the middle chamber, and finally to the outer waste area. Fluid is moved between the different areas by rotation on a central drive that produces sufficient centrifugal force to allow the fluid transfers. The lid is a flexible plastic mould that closes tightly over the bottom part, forming a flat cylindrical cassette that can be turned from the bottom by the action of a peripheral drive. Two holes are punched through the plastic to allow addition of the sample and wash reagent into the middle chamber (sample hole) and the addition of fluid into the inner area of the chamber to pick up the coated microbead conjugate (inner hole). The bottom part can be moved relative to the lid to two fixed positions (clockwise and counterclockwise) that open and close valves in the cassette. In one position, holes between the inner area and middle chamber are . . . [Full Text of this Article]

Detection and quantification of a soluble antigen.

Detection and quantification of an antiserum (serology).