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Clinical Chemistry 46: 145-146, 2000;
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(Clinical Chemistry. 2000;46:145-146.)
© 2000 American Association for Clinical Chemistry, Inc.

Editorials

The Potential Use of Glutathionyl Hemoglobin as a Clinical Marker of Oxidative Stress

Sven-Erik Bursella,1

a Author for correspondence. Fax 617-732-2545; e-mail sbursell@joslin.harvard.edu.

George L. King1

1 Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215

Over the past decade, there has been substantial interest in oxidative stress and its potential role in the development of disease-related pathophysiological complications in diabetes (1)(2), atherosclerosis and associated cardiovascular disease (3)(4), cancer (5), aging (6), and other conditions. "Oxidative stress" refers to an imbalance between antioxidant and oxidant-generating systems. An increase in oxidative stress can have a profound effect on lipoprotein modification, transcription, and cell function and metabolism. Oxidative stress can arise via various mechanisms associated with excessive oxygen radical production, such as autooxidation of glucose and glycated proteins, and glycation of antioxidant enzymes. Even in healthy subjects, hyperglycemia, increased free fatty acids, and hyperinsulinemia can trigger oxidative stress (7). In diabetes, increased blood concentrations of markers of oxidative stress, especially in patients with poor glycemic control (8)(9), have been implicated in the development of vascular complications. The finding of increased oxidative stress in newly diagnosed children and diabetic patients with no complications (8) suggests that the increased oxidative stress in diabetes may not be attributable to the complications but could contribute to the development of complications. Other studies in patients with increased concentrations of plasma lipoproteins (10) have implicated increased oxidative stress with associated . . . [Full Text of this Article]


References




The following articles in journals at HighWire Press have cited this article:


Home page
 Hum Mol GenetHome page
F. Auchere, R. Santos, S. Planamente, E. Lesuisse, and J.-M. Camadro
Glutathione-dependent redox status of frataxin-deficient cells in a yeast model of Friedreich's ataxia
Hum. Mol. Genet., September 15, 2008; 17(18): 2790 - 2802.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
D. Giustarini, I. Dalle-Donne, R. Colombo, S. Petralia, S. Giampaoletti, A. Milzani, and R. Rossi
Protein Glutathionylation in Erythrocytes
Clin. Chem., February 1, 2003; 49(2): 327 - 330.
[Full Text] [PDF]


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