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Technical Briefs |
1
Institute for Clinical Chemistry, University of Magdeburg, D-39120 Magdeburg, Germany;
2
Institute for Clinical Chemistry, Uppsala Academic Hospital, S-75185 Uppsala, Sweden;
3
4th Clinical Department, University of Leipzig, D-04103 Leipzig, Germany;
4
Central Laboratory, Bonifatius Hospital, D-49809 Lingen/Ems, Germany;
5
Central Laboratory, Karlsburg Clinic, D-17495 Karlsburg, Germany;
6
Joslin Diabetes Center, Boston, MA 02215;
7
Department of Endocrinology, University Hospital Vrije Universiteit, NL-1007 MB Amsterdam, The Netherlands;
8
Evaluation Patient Care, Roche Diagnostics GmbH, D-68298 Mannheim, Germany;
9
Accu-Chek, Accutrend, COBAS, Precilip, and Precinorm are trademarks of a member of the Roche Group.
a author for correspondence: fax 49-391-67-13902, e-mail claus.luley@medizin.uni-magdeburg.de
The importance of triglycerides in the development of atherosclerosis is currently receiving increasing attention in view of the growing evidence that triglycerides constitute an independent risk factor for cardiovascular disease (1). The atherogenicity of hypertriglyceridemia is particularly apparent not only in fully developed type 2 diabetes mellitus, but also in individuals with a complete or incomplete metabolic syndrome. The four prominent symptoms of the latter (hypertriglyceridemia, abdominal obesity, insulin resistance, and hypertension) have even been named "the deadly quartet" (2). The pathological processes linking triglyceride-rich lipoproteins with the appearance and growth of atheromas are complex. Triglyceride-rich lipoproteins themselves may be involved, or their remnant products, or low concentrations of HDL-cholesterol, which are most frequently found in association with hypertriglyceridemia (3). Not only fasting triglycerides have been shown to be associated with atherosclerosis (4)(5)(6), but also postprandial triglycerides, which can reach remarkably high concentrations (4).
Glucose is a regularly controlled variable in patients suffering from
diabetes mellitus or the metabolic syndrome. Glucose testing is
performed not only in doctors’ offices but also by the patients at
home, using glucose-specific point-of-care testing devices. In
contrast, triglycerides, which similarly to glucose exhibit a
considerable variation throughout the day that is related mainly to
food intake, could not be monitored in this way because of a lack of
corresponding point-of-care testing instrumentation. The development of
such a device for rapid point-of-care triglyceride measurement,
therefore, appeared advantageous, allowing as it does rapid monitoring
of triglycerides by both doctors and patients. Although no cutpoints at
which postprandial triglycerides increase the risk of cardiovascular
disease are defined at present, information about a patient’s
metabolic status with respect to triglycerides throughout the day and
use of this information to reduce triglyceride concentrations
throughout the
Acknowledgments
References
The following articles in journals at HighWire Press have cited this article:
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  A. D. Flouris, B. E. Faught, and P. Klentrou Cardiovascular disease risk in adolescent smokers: evidence of a `smoker lifestyle' J Child Health Care, September 1, 2008; 12(3): 221 - 231. [Abstract] [PDF]
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 J. Ribalta, C. J.M. Halkes, J. Salazar, L. Masana, and M. C. Cabezas Additive Effects of the PPAR{gamma}, APOE, and FABP-2 Genes in Increasing Daylong Triglycerides of Normolipidemic Women to Concentrations Comparable to Those in Men Clin. Chem., May 1, 2005; 51(5): 864 - 871. [Abstract] [Full Text] [PDF]
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 J. P. van Wijk, M. C. Cabezas, C. J. Halkes, and D W. Erkelens Effects of different nutrient intakes on daytime triacylglycerolemia in healthy, normolipemic, free-living men Am. J. Clinical Nutrition, August 1, 2001; 74(2): 171 - 178. [Abstract] [Full Text] [PDF]
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