HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit an electronic Letter to the Editor about this paper Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (23) Citing Articles via Google Scholar Google Scholar Articles by Ghani, F. Articles by Brown, M. Search for Related Content PubMed PubMed Citation Articles by Ghani, F. Articles by Brown, M. Related Collections Proteomics and Protein Markers

Role of Heart-Type Fatty Acid-binding Protein in Early Detection of Acute Myocardial Infarction

¹ Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, CT 06102

² New Britain General Hospital, New Britain, CT 06050

³ Bayer Diagnostics, Tarrytown, NY 10591

⁴ Winthrop University Hospital, Mineola, Long Island, NY 11501
^a author for correspondence: fax 860-545-3733, e-mail fghani@harthosp.org

Biochemical evidence of acute myocardial infarction (AMI) is delayed by the delay of appearance of serum cardiac markers in the blood after myocardial injury. Heart-type fatty acid-binding protein (H-FABP), a small (15 kDa) cytoplasmic protein (1) involved in lipid homeostasis, is abundant in heart muscle (2). H-FABP is ~10-fold lower in skeletal muscle than in heart muscle, and the amounts in the kidney, liver, and small intestine are even lower (3). After myocardial damage, H-FABP is released into the intercellular space and appears in the bloodstream (4). The magnitude of the increase in plasma H-FABP has also demonstrated a good correlation with the size of the infarction (5). Myoglobin, another small protein (18 kDa), appears in the plasma within 2–3 h after myocardial infarction and is considered a useful marker in the early detection of AMI (6). Myoglobin lacks specificity because myoglobin released from skeletal muscles cannot be distinguished from that released from the heart. Cardiac troponin I (cTnI) and creatine kinase MB isoenzyme (CK-MB) are more specific for myocardial injury but lack early sensitivity because their blood concentrations do not increase appreciably until 6–8 h after the onset of AMI (7).

The aim of this multicenter study was to compare H-FABP with myoglobin, cTnI, and CK-MB . . . [Full Text of this Article]

References

The following articles in journals at HighWire Press have cited this article:

				F. S. Apple, S. W. Smith, L. A. Pearce, and M. M. Murakami Assessment of the Multiple-Biomarker Approach for Diagnosis of Myocardial Infarction in Patients Presenting with Symptoms Suggestive of Acute Coronary Syndrome Clin. Chem., January 1, 2009; 55(1): 93 - 100. [Abstract] [Full Text] [PDF]

				P. Mad, H. Domanovits, C. Fazelnia, K. Stiassny, G. Russmuller, A. Cseh, G. Sodeck, T. Binder, G. Christ, T. Szekeres, et al. Human heart-type fatty-acid-binding protein as a point-of-care test in the early diagnosis of acute myocardial infarction QJM, April 1, 2007; 100(4): 203 - 210. [Abstract] [Full Text] [PDF]