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Clinical Chemistry 46: 879, 2000;
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(Clinical Chemistry. 2000;46:879.)
© 2000 American Association for Clinical Chemistry, Inc.

Letters

Urinary Free Cortisol Is Unrelated to Physiological Changes in Urine Volume in Healthy Women

Pietro Putignano, Antonella Dubini and Francesco Cavagninia

Department of Endocrinology, University of Milan, Istituto Scientifico Ospedale San Luca, Istituto Auxologico Italiano, Via Spagnoletto 3, 20149 Milano, Italy
a Author for correspondence. Fax 39-02-58216777; e-mail cavagnini@auxologico.it.


To the Editor:

Urinary free cortisol is largely accepted as an accurate means of assessing daily cortisol secretion. A more precise definition of this marker should be "urinary free corticoids" (UFCs), because all competitive binding assays overestimate free cortisol in urine (1). Recently, it has been argued that urine volume may be a confounding factor because high fluid intake has been reported to significantly increase UFCs in healthy subjects (2), and an earlier study also stated that UFC concentrations are closely related to changes in urine volume in children (3). Conversely, a recent study published in Clinical Chemistry reported . . . [Full Text of this Article]


References




The following articles in journals at HighWire Press have cited this article:


Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
C. A. Rideout, W. Linden, and S. I. Barr
High cognitive dietary restraint is associated with increased cortisol excretion in postmenopausal women.
J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2006; 61(6): 628 - 633.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. Fenske
How Much "Urinary Free Cortisol" Is Really Cortisol during Water Diuresis in Healthy Individuals?
Clin. Chem., June 1, 2004; 50(6): 1102 - 1104.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
B. E. P. Murphy
How Much ""UFC"" Is Really Cortisol?
Clin. Chem., June 1, 2000; 46(6): 793 - 794.
[Full Text] [PDF]


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