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Clinical Chemistry 46: 1015-1016, 2000;
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(Clinical Chemistry. 2000;46:1015-1016.)
© 2000 American Association for Clinical Chemistry, Inc.

Letters

Thyroid Function during Pregnancy

Nobuyuki Amino1,a, Hisato Tada1, Yoh Hidaka1 and Yukiko Izumi1

1 Department of Laboratory Medicine, Osaka University, Graduate School of Medicine D2, 2-2 Yamadaoka Suita, Osaka 565-0871, Japan
a Author for correspondence. Fax 81-6-6879-3239; e-mail namino@labo.med.osaka-u.ac.jp.


To the Editor:

We read with interest the case conference by Fantz et al. (1) on thyroid function during pregnancy. The presented case is typical of gestational thyrotoxicosis (2), and the authors reviewed beautifully the related problems of interpretation of thyroid function tests in pregnancy.

We had proposed a new clinical entity, "gestational thyrotoxicosis", defined by clinical features as follows (3): (a) thyrotoxic symptoms, such as palpitation, increased sweating, and weight loss in early pregnancy; (b) marked increase in free thyroxine (T4; more than twice the upper limit of the reference range) and free triiodothyronine (T3); (c) complication with hyperemesis gravidarum; (d) spontaneous recovery in the later half of pregnancy; (e) negative for . . . [Full Text of this Article]


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