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Technical Briefs |
1
Departments of Pediatrics and
2
Obstetrics and Gynecology, Giannina Gaslini Children’s University Hospital, I-16147 Genoa, Italy
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Institute of Anatomy, Catholic University, I-00168 Rome, Italy
4
Laboratory of Perinatal Medicine and Molecular Biology, University "La Sapienza", I-00124 Rome, Italy
a address
correspondence to this author at: Institute of Anatomy, Catholic University, Largo Francesco Vito 1, I-00168 Rome, Italy. Fax 39-063051343, e-mail fabrizio.michetti@rm.unicatt.it
S100B is an acidic calcium-binding protein of the EF-hand family concentrated in the nervous system, where it is located mainly in glial cells (1). Although many hypotheses have been formulated, its biological role is still debated, but its appearance in biological fluids has been shown to be a reliable index of brain distress (2).
We investigated the relationship between S100B concentrations in cord blood and gestational age in the third trimester of pregnancy in normal preterm and term deliveries.
We investigated 58 women with consecutive singleton physiological pregnancies (30 at term and 28 preterm), with normal flow velocimetry waveforms in the uteroplacental vessels, whose delivery was between 27 and 42 weeks of gestation. Gestational age was determined by clinical data and by a first-trimester ultrasound scan. Appropriate growth was defined by the presence of ultrasonographic signs (when biparietal diameter and abdominal circumference were between the 10th and 90th centiles) according to the normograms of Campbell and Thoms (3) and by postnatal confirmation of a birth weight between the 10th and 90th centiles according to our population standards after correction for the mother’s height, weight, and parity, and the sex of the newborn. Exclusion criteria were multiple pregnancies, intrauterine growth retardation, gestational hypertension, diabetes and infections, fetal malformations, chromosomal abnormalities, perinatal asphyxia, and dystocia.
The study protocol was approved by the Ethics Committee of the Giannina
Gaslini Children’s Hospital, Genoa University; the parents of
References
The following articles in journals at HighWire Press have cited this article:
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  A. P. Schmidt, A. B.L. Tort, O. B. Amaral, A. P. Schmidt, R. Walz, J. Vettorazzi-Stuckzynski, S. H. Martins-Costa, J. G. L. Ramos, D. O. Souza, and L. V.C. Portela Serum S100B in Pregnancy-Related Hypertensive Disorders: A Case-Control Study Clin. Chem., February 1, 2004; 50(2): 435 - 438. [Full Text] [PDF]
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 D. Gazzolo, E. Marinoni, R. Di Iorio, M. Bruschettini, M. Kornacka, M. Lituania, U. Majewska, G. Serra, and F. Michetti Measurement of Urinary S100B Protein Concentrations for the Early Identification of Brain Damage in Asphyxiated Full-term Infants Arch Pediatr Adolesc Med, December 1, 2003; 157(12): 1163 - 1168. [Abstract] [Full Text] [PDF]
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D. Gazzolo, M. Kornacka, M. Bruschettini, M. Lituania, L. Giovannini, G. Serra, U. Majewska, and F. Michetti Maternal Glucocorticoid Supplementation and S100B Protein Concentrations in Cord Blood and Urine of Preterm Infants Clin. Chem., July 1, 2003; 49(7): 1215 - 1218. [Full Text] [PDF]
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D. Gazzolo, F. Michetti, M. Bruschettini, N. Marchese, M. Lituania, S. Mangraviti, E. Pedrazzi, and P. Bruschettini Pediatric Concentrations of S100B Protein in Blood: Age- and Sex-related Changes Clin. Chem., June 1, 2003; 49(6): 967 - 970. [Full Text] [PDF]
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D. Gazzolo, M. Lituania, M. Bruschettini, P. Bruschettini, and F. Michetti S100B Protein Concentrations in Amniotic Fluid Are Higher in Monoamniotic than in Diamniotic Twins and Singleton Pregnancies Clin. Chem., June 1, 2003; 49(6): 997 - 999. [Full Text] [PDF]
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F. Michetti and D. Gazzolo S100B Protein in Biological Fluids: A Tool for Perinatal Medicine Clin. Chem., December 1, 2002; 48(12): 2097 - 2104. [Abstract] [Full Text] [PDF]
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L. V.C. Portela, A. B.L. Tort, D. V. Schaf, L. Ribeiro, D. B. Nora, R. Walz, L. N. Rotta, C. T. Silva, J. V. Busnello, F. Kapczinski, et al. The Serum S100B Concentration Is Age Dependent Clin. Chem., June 1, 2002; 48(6): 950 - 952. [Full Text] [PDF]
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D. Gazzolo, M. Bruschettini, R. Di Iorio, E. Marinoni, M. Lituania, M. Marras, R. Sarli, P. L. Bruschettini, and F. Michetti Maternal Nitric Oxide Supplementation Decreases Cord Blood S100B in Intrauterine Growth-retarded Fetuses Clin. Chem., April 1, 2002; 48(4): 647 - 650. [Full Text] [PDF]
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D. Gazzolo, M. Bruschettini, M. Lituania, G. Serra, W. Bonacci, and F. Michetti Increased Urinary S100B Protein as an Early Indicator of Intraventricular Hemorrhage in Preterm Infants: Correlation with the Grade of Hemorrhage Clin. Chem., October 1, 2001; 47(10): 1836 - 1838. [Full Text] [PDF]
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D. Gazzolo, M. Bruschettini, M. Lituania, G. Serra, E. Gandullia, and F. Michetti S100B Protein Concentrations in Urine Are Correlated with Gestational Age in Healthy Preterm and Term Newborns Clin. Chem., June 1, 2001; 47(6): 1132 - 1133. [Full Text] [PDF]
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D. Gazzolo, M. Bruschettini, V. Corvino, R. Oliva, R. Sarli, M. Lituania, P. Bruschettini, and F. Michetti S100B Protein Concentrations in Amniotic Fluid Correlate with Gestational Age and with Cerebral Ultrasound Scanning Results in Healthy Fetuses Clin. Chem., May 1, 2001; 47(5): 954 - 956. [Full Text] [PDF]
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