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Clinical Chemistry 46: 1438-1439, 2000;
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(Clinical Chemistry. 2000;46:1438-1439.)
© 2000 American Association for Clinical Chemistry, Inc.

Letters

Fluorogenic Probes to Detect the A-444C Transversion in the Leukotriene C4 Synthase Promoter

Simone Neemeshkanna1, Olfert Landt2, Hans F. Merk1 and Brunhilde Blömeke1,a

1 Department of Dermatology, University Hospital, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany

2 TIB MOLBIOL, Tempelhofer Weg 11-12, 10829 Berlin, Germany
a Address correspondence to this author at: Department of Dermatology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany. Fax 49-241-88-88-413; e-mail B.BLOEMEKE@RWTH-AACHEN.DE.


To the Editor:

Adverse hypersensitivity reactions to aspirin and other nonsteroidal antiinflammatory drugs (1) resemble pseudoallergic reactions with bronchospasm, chronic rhinoconjunctivitis, nasal polyps, urticaria, angioedema, life-threatening bronchospasm, and anaphylactic shock (2). Up to 25% of hospital admissions for acute asthma may be caused by nonsteroidal antiinflammatory drug ingestion. In aspirin-induced asthma, cysteine-leukotriene release into airways (3)(4) is associated with increased concentrations of leukotriene C4 synthase, the enzyme that forms leukotriene C4 [for review, see Ref. (5)]. A polymorphism in the promoter region of the gene for leukotriene C4 synthase predisposes to disease (4). The A-444C transversion creates a new MspI restriction site.

PCR-restriction fragment length polymorphism analysis has been used to detect this . . . [Full Text of this Article]


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