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Clinical Chemistry 48: 1796-1797, 2002;
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(Clinical Chemistry. 2002;48:1796-1797.)
© 2002 American Association for Clinical Chemistry, Inc.

Technical Briefs

Total ß-Human Chorionic Gonadotropin Measured in Urine by an Automated Method

Mary O. Carayannopoulos, David G. Grenache and Ann M. Gronowskia

1 Department of Pathology and Immunology, Division of Laboratory Medicine, Washington University School of Medicine, 660 South Euclid Ave., Box 8118, St. Louis, MO 63110

aauthor for correspondence: fax 314-362-1461, e-mail gronowski@pathology.wustl.edu

The first 20% of the full text of this article appears below.

Methods to quantify human chorionic gonadotropin (hCG) in serum are well established (1), but automated quantitative urine assays are not readily available. When the validity of point-of-care qualitative urine hCG results are called into question, a rapid quantitative method for urine hCG could be useful. In the present study, we have validated the Abbott AxSYM Total ß-hCG (Abbott Laboratories) assay (approved for serum use only) for use in the quantitative determination of urinary concentrations of total ß-hCG.

Recovery studies were performed by adding hCG (US Pharmacopeia) to urine from premenopausal, nonpregnant females. Recovery studies were carried out in quadruplicate in two separate experiments. Recovery was 99–112% at concentrations of 26–725 IU/L (Table 1 ). Urine protein at concentrations up to 7.4 g/L had no effect on recovery (not shown).


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  		Table 1. Recovery of total ß-hCG from urine by the Abbott AxSYM.

Intra- and interassay imprecision was . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
A. M. Halldorsdottir, M. O. Carayannopoulos, M. Scrivner, and A. M. Gronowski
Method Evaluation for Total {beta}-Human Chorionic Gonadotropin Using Urine and the ADVIA Centaur
Clin. Chem., August 1, 2003; 49(8): 1421 - 1422.
[Full Text] [PDF]


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