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Clinical Chemistry 48: 2289-a, 2002;
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(Clinical Chemistry. 2002;48:2289.)
© 2002 American Association for Clinical Chemistry, Inc.

Letters

Falsely Increased Thyroid-stimulating Hormone Concentrations attributable to Interference from Human Anti-mouse Antibodies

Françoise Flourié1a, François Parant1, Marie Christine Pénès1 and Dany Alcaraz-Galvain2

1 Laboratoire de Biochimie, Hôpital Edouard Herriot, 5, Place d’Arsonval, Lyon 69437, France

2 Service de Techníques, Nucléaires et Biophysiques, Centre Hospitalier Lyon Sud, Pierre-Bénite 69495, France

aAuthor for correspondence. Fax 33-4-7211-0597.

The first 20% of the full text of this article appears below.


To the Editor:

We describe a case of a spurious increase in serum thyroid-stimulating hormone (TSH) attributed to a circulating human anti-mouse antibody (HAMA) in a two-site mouse monoclonal antibody-based assay.

A 71-year-old woman on long-term levothyroxine therapy was referred for investigation of uveitis. Her serum TSH had been maintained within the usual reference interval for more than a decade. The initial TSH value by an immunometric method (assay A) on the Dimension RxL analyzer (Dade Behring) was 7.5 mIU/L (reference interval, 0.34–4.82 mIU/L). Because . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
R. Sapin, A. Agin, and F. Gasser
Misleading High Thyrotropin Results Obtained with a Two-Site Immunometric Assay Involving a Chimeric Antibody
Clin. Chem., May 1, 2004; 50(5): 946 - 948.
[Full Text] [PDF]


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