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Clinical Chemistry 48: 353-354, 2002;
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(Clinical Chemistry. 2002;48:353-354.)
© 2002 American Association for Clinical Chemistry, Inc.

Technical Briefs

Increased Cell-free Fetal DNA in Plasma of Two Women with Invasive Placenta

Akihiko Sekizawa1a, Masatoshi Jimbo1, Hiroshi Saito1, Mariko Iwasaki1, Yumi Sugito1, Yasuo Yukimoto1, Junko Otsuka1 and Takashi Okai1

1 Department of Obstetrics and Gynecology, Showa University School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan

aauthor for correspondence: fax 81-33784-8355, e-mail sekizawa@d8.dion.ne.jp

Invasive placenta, often involving placenta accreta, placenta increta, and placenta percreta, is a life-threatening complication of pregnancy characterized by invasion of placental villi into the underlying myometrium. Invasive placenta is usually diagnosed as a result of abnormalities encountered during removal of the placenta at delivery. Because of profuse hemorrhaging in the early postpartum period, blood transfusion or emergency hysterectomy is often required in patients with invasive placenta. Invasive placenta is also associated with high maternal morbidity and a high risk of mortality. Therefore, prenatal prediction of this disease would be of great clinical benefit.

Recently, Lo et al. (1) discovered the presence of fetal DNA in maternal plasma. They developed a real-time quantitative PCR assay with which to measure the concentration of fetal DNA within maternal plasma. In addition, they analyzed the Y-chromosome-specific SRY sequence to quantify the number of genome equivalents per milliliter of plasma in women carrying male fetuses (2). Although cell-free fetal DNA is reported to increase in maternal plasma in cases of preterm delivery (3), preeclampsia (4)(5), and pregnancy with a trisomy 21 fetus (6), it is unclear . . . [Full Text of this Article]


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References




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