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Clinical Chemistry 48: 1133, 2002;
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(Clinical Chemistry. 2002;48:1133.)
© 2002 American Association for Clinical Chemistry, Inc.

Letters

IgG Anti-Transglutaminase Autoantibodies in Systemic Lupus Erythematosus and Sjögren Syndrome

Danilo Villalta1, Nicola Bizzaro2a, Elio Tonutti3 and Renato Tozzoli4

1 Servizio di Immunologia e Microbiologia, Azienda Ospedaliera, S. Maria degli Angeli, 33170 Pordenone, Italy

2 Laboratorio di Patologia Clinica, Ospedale Civile, 30027 S. Donà di Piave (VE), Italy

3 Istituto di Chimica Clinica, Azienda Ospedaliera, S. Maria della Misericordia, 33100 Udine, Italy

4 Dipartimento di Medicina di Laboratorio, Ospedale Civile, 33053 Latisana (UD), Italy

aAuthor for correspondence. Fax 39-0421-227571; e-mail nbizzaro@dacos.it.

The first 20% of the full text of this article appears below.


To the Editor:

In a recent issue of this journal, van der Sluijs Veer and Vermes (1) reported a high prevalence and concentration of IgG anti-tissue transglutaminase (anti-tTG) antibodies in patients with systemic lupus erythematosus (SLE) and increased anti-dsDNA antibodies, as well as in anti-SSA/SSB-positive patients. No increase was observed in patients with other autoantibodies, such as anti-Sm/RNP, anti-nucleolar, anti-histidyl-tRNA synthetase, anti-centromere protein B, anti-topoisomerase I, anti-proteinase 3, and IgM rheumatoid factor, or in patients with chronic inflammation. The authors proposed that in situations involving an imbalance between the supply and clearance of apoptotic bodies (as demonstrated in SLE), the immune system may detect intracellular tTG-substrate protein complexes, leading to . . . [Full Text of this Article]






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Copyright © 2002 by the American Association for Clinical Chemistry.