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Clinical Chemistry 48: 1626, 2002;
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(Clinical Chemistry. 2002;48:1626.)
© 2002 American Association for Clinical Chemistry, Inc.

Letters

Representatives of INOVA Diagnostics respond to the letter by Drs. Hoefner and Yeo:

Walter L. Bindera and Brys Myers

INOVA Diagnostics Inc., San Diego, CA 92131-123

aAuthor for correspondence.

The first 20% of the full text of this article appears below.


To the Editor:

Anticardiolipin antibody (ACA) tests are among the most difficult of all ELISAs to standardize. There are the well-known difficulties of adhering the phospholipid to a plastic microwell plate. In addition, the antigen solid phase is complex, consisting of both the phospholipid plus a necessary cofactor, known as ß2-glycoprotein (ß2-GPI), and the blocking agent. Then there is the added problem of having to calibrate each reagent set to a reference preparation that consists of pooled human . . . [Full Text of this Article]






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Copyright © 2002 by the American Association for Clinical Chemistry.