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Clinical Chemistry 49: 523-525, 2003; 10.1373/49.3.523
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(Clinical Chemistry. 2003;49:523-525.)
© 2003 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Serum Concentrations of Vascular Endothelial Growth Factor in Advanced Non-Small Cell Lung Cancer

Jaume Trapé1a, Josep Buxó2 and Joaquim Pérez de Olaguer2

1 Laboratori Anàlisis Clíniques, and,
2 Secció Oncologia, Hospital General de Manresa, Althaia Xarxa Asistencial de Manresa, La Culla, s/n, 08240 Manresa (Barcelona), Spain

aAuthor for correspondence. Fax 34-93-8743859; e-mail hgmlaboratorio@aehh.org.

The first 20% of the full text of this article appears below.


To the Editor:

Vascular endothelial growth factor (VEGF) may play a role in tumor growth. Several biological activities of VEGF favor the growth of solid tumors, including mitogenic activity for vascular endothelial cells and inhibition of immature dendritic cells with a consequent decrease in immunity. VEGF is regulated by hypoxia, growth factors, interleukin-1 and -6, the oncogene ras, and the tumor suppressor gene p53 (1).

The role of VEGF in non-small cell lung cancer (NSCLC) patients treated with chemotherapy in still undetermined. We studied the serum concentrations of this cytokine in NSCLC patients with advanced disease and its correlation with carcinoembryonic antigen (CEA), CYFRA 21-1, CA125, and C-reactive protein (CRP).

We analyzed 33 healthy individuals, 23 patients with benign pulmonary disease (13 with . . . [Full Text of this Article]




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