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Clinical Chemistry 50: 1828-1830, 2004; 10.1373/clinchem.2003.026963
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(Clinical Chemistry. 2004;50:1828-1830.)
© 2004 American Association for Clinical Chemistry, Inc.

Technical Briefs

Reference Intervals for Serum Calcitonin in Men, Women, and Children

Jean-Pierre Basuyau1,a, Eric Mallet2, Marcelle Leroy1 and Philippe Brunelle1

1 Laboratoire de Biologie Clinique et de Radioanalyse, Centre Henri-Becquerel, Rouen, France;
2 Service de Pédiatrie, Hôpital Charles-Nicolle, CHU de Rouen, France;

aauthor for correspondence: fax 33-2-32-082590, e-mail jeabas@rouen.fnclcc.fr

The first 20% of the full text of this article appears below.

The strategy currently used to investigate thyroid nodules in most cases involves measurement of calcitonin to exclude the possibility of medullary thyroid cancer (MTC). Techniques used to measure calcitonin have become more reliable, sensitive, and easy to perform. Automated nonisotopic techniques now exist, such as the Advantage® system.

We found that some children have particularly high calcitonin. Previous reports also have shown that calcitonin is higher in young children (1)(2)(3)(4)(5)(6)(7)(8)(9), but most of these studies are now outdated and are based on immunoradiometric or even radioimmunologic (RIA) methods, which sometimes involve an extraction step. These techniques are also not very sensitive or specific (interference by procalcitonin). Because most studies addressing this subject investigated specific populations (premature infants, newborns, or hypotrophic or hypocalcemic children), we concluded that it would be useful to determine reference intervals for blood calcitonin in children with the Advantage system. Because the manufacturer (Nichols Institute Diagnostics) found a significant difference between men and women, we also evaluated this finding.

The Advantage is an automated multiparametric random-access system that uses an acridinium ester chemiluminescence technique and a magnetic separation step (10)(11). The monoclonal antibodies used recognize the 11–23 (capture monoclonal antibody) and 21–32 (labeled monoclonal . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


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 Eur J EndocrinolHome page
M. d'Herbomez, P. Caron, C. Bauters, C. Do Cao, J.-L. Schlienger, R. Sapin, L. Baldet, B. Carnaille, J.-L. Wemeau, and the French Group GTE (Groupe des Tumeurs Endocrine
Reference range of serum calcitonin levels in humans: influence of calcitonin assays, sex, age, and cigarette smoking
Eur. J. Endocrinol., December 1, 2007; 157(6): 749 - 755.
[Abstract] [Full Text] [PDF]


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