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Clinical Chemistry 50: 2389-2391, 2004; 10.1373/clinchem.2004.038208
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(Clinical Chemistry. 2004;50:2389-2391.)
© 2004 American Association for Clinical Chemistry, Inc.


Technical Briefs

Within-Person, Among-Finger Variability of Capillary Blood Glucose Measurements

Mary M. Kimberly1,a, Samuel P. Caudill1, Hubert W. Vesper1, Steven F. Ethridge2, Enada Archibold1, Kimberly H. Porter3 and Gary L. Myers1

1 Clinical Chemistry Branch, Division of Laboratory Sciences, National Center for Environmental Health, 2 Behavioral and Clinical Surveillance Branch, Division of HIV and AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA; and 3 International Medical Press, Atlanta, GA

aaddress correspondence to this author at: Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Mailstop F25, 4770 Buford Hwy NE, Atlanta, GA 30341-3724; fax 770-488-4192, e-mail mkimberly@cdc.gov

The first 20% of the full text of this article appears below.

Many diabetic patients use home-use glucose monitors for glycemic control (1)(2). Ideally, in studies comparing and assessing the variability among monitors, testing should be done with the same type of sample used by patients, i.e., capillary whole blood. Simultaneous evaluation of multiple monitors requires more sample than can effectively be collected by lancing a single finger one or more times. Samples may therefore need to be collected from multiple fingers, and if so, the among-finger variability will need to be quantified before a study of among-monitor variability can be conducted. To our knowledge, no studies have been published that report among-finger variability in blood glucose measurements within an individual patient. Because evaluation of multiple monitors using multiple samples from an individual also assumes that the within-person blood glucose will be stable for the duration of the testing period, we tested, in a pilot study using a HemoCue 201 point-of-care glucose analyzer, the assumptions that the within-person, among-finger variability (hereafter referred to as "among-finger" variability) is negligible and that the within-person blood glucose is stable over a period of 35 min.

The Institutional Review Boards at the CDC and at Research Triangle Institute (where the study was conducted) approved the protocol. Free-living, community-dwelling people recruited from the Raleigh-Durham-Chapel . . . [Full Text of this Article]







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