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Clinical Chemistry 50: 2460-2461, 2004; 10.1373/clinchem.2004.038521
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(Clinical Chemistry. 2004;50:2460-2461.)
© 2004 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Stability of Whole Blood at –70 °C for Measurement of Hemoglobin A1c in Healthy Individuals

Wendy Jones1,a, Jeff Scott3, Sam Leary2, Fay Stratton2, Susan Smith2, Richard Jones2, Andrew Day3, Andrew Ness2 and ALSPAC Study Team2

1 Department of Social Medicine and2 Avon Longitudinal Study of Parents and Children, University of Bristol, Bristol, UK
3 Department of Clinical Biochemistry, United Bristol Healthcare NHS Trust, Bristol, UK

aAddress correspondence to this author at: Department of Social Medicine, University of Bristol, Bristol, UK BS8 2PR. E-mail W.A.Jones@bristol.ac.uk.

The first 20% of the full text of this article appears below.


To the Editor:

To our knowledge, there are no significant published data on the long-term stability of stored whole blood for hemoglobin A1c (HbA1c) analysis Stored hemolysates (1) and buffy coat samples (2) can provide reliable estimates of HbA1 and HbA1c, respectively; in large epidemiologic studies, however, storage of whole blood would be more practical. A recent report stated that whole blood was stable at –70 °C for 1 year, but no evidence was cited (3). The aim of this study was therefore to test the hypothesis that whole blood is stable at –70 °C for 1 year for HbA1c measurement.

Venous blood was collected from 99 children (age, 10 years) without diabetes over a 3-week period in the Avon Longitudinal Study of Parents and Children (ALSPAC; www.alspac.bris.ac.uk). The anticoagulant . . . [Full Text of this Article]






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