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Clinical Chemistry 50: 2465, 2004; 10.1373/clinchem.2004.040253
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(Clinical Chemistry. 2004;50:2465.)
© 2004 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Reference Values for N-Terminal Pro-B-Type Natriuretic Peptide in Umbilical Cord Blood

Jaap Bakker1,a, Inge Gies2, Barbara Slavenburg2, Otto Bekers1, Tammo Delhaas2 and Marja van Dieijen-Visser1

Departments of1 Clinical Chemistry and2 Pediatrics, University Hospital Maastricht, Maastricht, The Netherlands

aAddress correspondence to this author at: Department of Clinical Chemistry, University Hospital Maastricht, PO Box 5800, NL-6202 AZ Maastricht, The Netherlands. Fax 31-43-3874667; e-mail j.bakker@klinchem.azm.nl.

The first 20% of the full text of this article appears below.


To the Editor:

Plasma concentrations of B-type natriuretic peptide (BNP), a 32-amino acid peptide hormone secreted by the myocardium, increase in response to myocardial stretch or strain (1)(2). On secretion, proBNP, the storage form of BNP, is cleaved into the inactive N-terminal proBNP (NT-proBNP) and the endocrinologically active BNP. In patients with heart failure, plasma BNP concentrations are related to the severity of symptoms and underlying cardiac abnormality (3). It is also known that neonates show transient increases in both plasma NT-proBNP and BNP in the first days of life as a result of the increased left ventricular volume load . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


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A El-Khuffash, D Barry, K Walsh, P G Davis, and E J Molloy
Biochemical markers may identify preterm infants with a patent ductus arteriosus at high risk of death or severe intraventricular haemorrhage
Arch. Dis. Child. Fetal Neonatal Ed., November 1, 2008; 93(6): F407 - F412.
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A. El-Khuffash and E. J Molloy
Are B-type natriuretic peptide (BNP) and N-terminal-pro-BNP useful in neonates?
Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2007; 92(4): F320 - F324.
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A. Hammerer-Lercher, J. Mair, G. Tews, B. Puschendorf, and R. Sommer
N-Terminal Pro-B-Type Natriuretic Peptide Concentrations Are Markedly Higher in the Umbilical Cord Blood of Newborns than in Their Mothers
Clin. Chem., May 1, 2005; 51(5): 913 - 915.
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B. Bar-Oz, A. Lev-Sagie, I. Arad, L. Salpeter, and A. Nir
N-Terminal pro-B-Type Natriuretic Peptide Concentrations in Mothers just before Delivery, in Cord Blood, and in Newborns
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