Clinical Chemistry
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Clinical Chemistry 50: 1709-1711, 2004; 10.1373/clinchem.2004.036517
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(Clinical Chemistry. 2004;50:1709-1711.)
© 2004 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Labor Increases Maternal DNA Contamination in Cord Blood

Hideaki Masuzaki1,1, Kiyonori Miura1,a,1, Shoko Miura1, Koh-ichiro Yoshiura2, Christophe K. Mapendano2, Daisuke Nakayama1, Shuichiro Yoshimura1, Norio Niikawa2,3 and Tadayuki Ishimaru1

Departments of1 Obstetrics and Gynecology and2 Human Genetics Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
3 CREST, Japan Science and Technology Agency, Kawaguchi, Japan

aAddress correspondence to this author at: Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Fax 81-95-849-7365; e-mail kiyonori@net.nagasaki-u.ac.jp.

The first 20% of the full text of this article appears below.


To the Editor:

Both maternal cells and maternal DNA are often present in the umbilical cord blood (UCB) (1). When UCB is used for bone marrow transplantation (2), the presence of maternal cells in UCB plasma is a theoretical risk factor for graft-vs-host disease and may lead to vertical transfer of infectious agents to a fetus. Previous studies showed that elective cesarean section (C/S) reduces these risks (3). Placental alkaline phosphatase is higher in cord blood of cases with labor than those without it (4), suggesting that labor increases transplacental maternal-fetal microtransfusion. As maternal DNA was found in only 75% of UCB plasma samples (5), we aimed to determine whether labor itself influences the frequency of maternal DNA contamination in UCB.

We studied 97 pregnant women with normal pregnancies. In group A (19 women), C/S was performed after the beginning of labor (labor with C/S); . . . [Full Text of this Article]






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Copyright © 2004 by the American Association for Clinical Chemistry.