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Serum 25-Hydroxyvitamin D Is Unaffected by Multiple Freeze-Thaw Cycles

¹ Division of Endocrinology, Department of Medicine, and ² Department of Epidemiology and Biostatistics, University of California, San Francisco, 74 New Montgomery St., Suite 600, San Francisco, CA 94105

^aauthor for correspondence: fax 415-597-9213, e-mail dantoniucci@psg.ucsf.edu

The first 20% of the full text of this article appears below.

Vitamin D deficiency is a common disorder believed to affect as many as 57% of hospitalized patients (1) and 9–50% of outpatients, depending on the characteristics of the study population (2)(3)(4)(5)(6). Vitamin D deficiency can cause secondary hyperparathyroidism and, if severe, osteomalacia. Both of these conditions are associated with loss of bone density, and both are reversible by repletion of vitamin D (7)(8)(9)(10). Recently, the association of vitamin D deficiency with an increased risk for a broader range of diseases, such as prostate cancer (11)(12) and colon cancer(13), has come to attention. Dietary vitamin D supplementation has even been implicated in decreasing the risk of developing type 1 diabetes mellitus (14), and ultraviolet irradiation has been shown to decrease systolic blood pressure in patients with mild untreated hypertension (15). Determining whether vitamin D deficiency is present usually involves assessing the stores of vitamin D by measuring serum 25-hydroxyvitamin D (25OHD) concentrations, in combination with an assessment of parathyroid hormone concentrations. Currently, the preferred clinical 25OHD assay is a two-step procedure . . . [Full Text of this Article]

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