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Clinical Chemistry 51: 270-a-272-a, 2005; 10.1373/clinchem.2004.042218
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(Clinical Chemistry. 2005;51:270-272.)
© 2005 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Between-Laboratory Variability in Oligoclonal IgG Band Numbering

Diego Franciotta1,a, Carlo Avolio2 and Francesco Lolli3

1 Laboratory of Neuroimmunology, Istituto di Ricovero e Cura a Carattere Scientifico, Neurological Institute "C. Mondino", University of Pavia, Pavia, Italy
2 Department of Medical and Work Sciences, University of Foggia, Foggia, Italy
3 Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy

aAddress correspondence to this author at: Foundation "Neurological Institute C. Mondino", via Mondino 2, I-27100 Pavia, Italy. Fax 39-0382-380286; e-mail diego.franciotta@mondino.it.

The first 20% of the full text of this article appears below.


To the Editor:

The respective patterns of cerebrospinal fluid (CSF)-restricted oligoclonal IgG bands (OCBs) and assessment of their similarity in serum and CSF are important laboratory tools for evaluating immune-mediated inflammation of the central nervous system. OCB detection is the diagnostic laboratory tool of choice for multiple sclerosis (MS), in the initial, clinically isolated syndromes as well as in the primary progressive forms (1). The imperatives of diagnostic certainty and therapeutic timeliness have made this laboratory test mandatory.

Isoelectric focusing (IEF) with IgG immunodetection is the recommended technique for OCB measurements (1)(2). Many factors (e.g., variability in gel conductivity, quality of carrier ampholytes, and electroendosmosis) make IEF inherently difficult to standardize. Notwithstanding this shortcoming, the results of previously published studies on interlaboratory variability in OCB . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
D. Franciotta and F. Lolli
Interlaboratory Reproducibility of Isoelectric Focusing in Oligoclonal Band Detection
Clin. Chem., August 1, 2007; 53(8): 1557 - 1558.
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