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Clinical Chemistry 51: 1767, 2005; 10.1373/clinchem.2005.057885
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(Clinical Chemistry. 2005;51:1767.)
© 2005 American Association for Clinical Chemistry, Inc.

Editorials

Additive-Aggravated Assays: An Authoritative Answer

Larry J. Krickaa and Jason Y. Park

Department of Pathology & Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA

aAddress correspondence to this author at: Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104-4283.

The first 20% of the full text of this article appears below.

Immunoassay interferences are diverse in scope (1)(2)(3)(4)(5)(6)(7)(8) and are the subject of several recent large-scale studies (9)(10), opinions, and editorials (6)(11). Most interferences originate from components of the sample (e.g., human antianimal antibodies, lipid, bilirubin, drug metabolites) that interact with assay reagents or the detection system.

The latest interference to rear its ugly head has been an interference originating from an additive in a blood collection tube (12)(13)(14). In this issue of Clinical Chemistry, Remaley et al. (13) have extended their original work (12) on this problem and have . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
L. J. Kricka, J. Y. Park, M. B. Senior, and R. Fontanilla
Processing Controls in Blood Collection Tubes Reveals Interference
Clin. Chem., December 1, 2005; 51(12): 2422 - 2423.
[Full Text] [PDF]


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