Clinical Chemistry
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Clinical Chemistry 51: 1903a-1904a, 2005; 10.1373/clinchem.2005.055038
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(Clinical Chemistry. 2005;51:1903a-1904.)
© 2005 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Ready Detection of Donor-Specific Single-Nucleotide Polymorphisms in the Urine of Renal Transplant Recipients by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

Ying Li1, Deirdré Hahn2, Wolfgang Holzgreve1 and Sinuhe Hahn1,a

1 University Women’s Hospital, University of Basel, Basel, Switzerland
2 Division of Paediatric Nephrology, University of the Witwatersrand, and Johannesburg Hospital, Johannesburg, South Africa

aAddress correspondence to this author at: Laboratory for Prenatal Medicine, University Women’s Hospital/Department of Research, Spitalstrasse 21, CH 4031 Basel, Switzerland. Fax 41-61-265-9399; e-mail shahn@unbs.ch.

The first 20% of the full text of this article appears below.


To the Editor:

Several studies have reported that transplant-derived cell-free DNA (CF-DNA) can be detected in the urine of renal transplant recipients (1)(2)(3)(4)(5). These studies have indicated that the increased excretion of CF-DNA is associated with acute graft rejection but not with drug-induced kidney dysfunction (1)(2)(3)(5).

A limitation of these studies was that they frequently relied on the detection of Y-chromosome–specific sequences in sex-disparate donor–recipient pairs (1)(2)(5). Although the use of specific human lymphocyte antigens mismatches was examined, this approach is reliably useful only when donor and recipient are unrelated (5). We previously reported that the analysis . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
Y. Li, W. Holzgreve, V. Kiefer, and S. Hahn
MALDI-TOF Mass Spectrometry Compared With Real-Time PCR for Detection of Fetal Cell-Free DNA in Maternal Plasma
Clin. Chem., December 1, 2006; 52(12): 2311 - 2312.
[Full Text] [PDF]


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Copyright © 2005 by the American Association for Clinical Chemistry.