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Clinical Chemistry 51: 2425, 2005; 10.1373/clinchem.2005.058644
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(Clinical Chemistry. 2005;51:2425.)
© 2005 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Increased Lipid Concentration Is Associated with Increased Hemolysis

Goce Dimeski1,a, Peter Mollee2 and Andrew Carter1

Departments of1 Chemical Pathology and2 Haematology, Queensland Health Pathology Service, Princess Alexandra Hospital, Woolloongabba, Australia

aAddress correspondence to this author at: Department of Chemical Pathology, Queensland Health Pathology Service, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland 4102, Australia. Fax 61-7-3240-7070; e-mail Goce_Dimeski@health.qld.gov.au.

The first 20% of the full text of this article appears below.


To the Editor:

The relationship between serum lipids and erythrocyte membrane fragility is complex (1). As seen in routine laboratory practice, samples with hypertriglyceridemia or mixed hypercholesterolemia and hypertriglyceridemia can present as visibly turbid ("milkshake" appearance), but more often they present as "strawberry milkshake" because of increased hemolysis. The amount of hemolysis appears to increase as the lipid concentration increases, although the extent of this effect is not well characterized.

We investigated whether a relationship exists between an increase in total lipid concentration (cholesterol plus triglycerides) and hemolysis in actual patient samples. To determine this relationship, we assessed all samples collected for lipid analysis during 2003 and 2004. Samples from the hospital emergency department were excluded because . . . [Full Text of this Article]






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