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Clinical Chemistry 51: 903-904, 2005; 10.1373/clinchem.2004.046151
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(Clinical Chemistry. 2005;51:903-904.)
© 2005 American Association for Clinical Chemistry, Inc.

Technical Briefs

Cystatin C Can Be Measured Reliably in Capillary Blood Samples

Sheila A.R. Kort1,a, Anna A. Bouman1, Marinus A. Blankenstein1 and Arend Bökenkamp2

Departments of1 Clinical Chemistry and 2 Pediatrics, VU University Medical Center Amsterdam, The Netherlands

aaddress correspondence to this author at: Department of Clinical Chemistry, VU University Medical Center Amsterdam, De Boelelaan 1117, 1081 HV, The Netherlands; fax 31-20-4443895, e-mail S.Kort@vumc.nl

The first 20% of the full text of this article appears below.

Cystatin C offers a promising alternative to serum creatinine as a marker of glomerular filtration (1)(2). In children, cystatin C is particularly useful because its concentration is constant after the age of 1 year (3). Unlike creatinine, cystatin C does not need to be corrected for weight or height to estimate glomerular filtration rate (4).

In young children, capillary blood sampling is often preferred over venipuncture and is used for many biochemical tests. Capillary blood is not suitable for all biochemical tests, however, because it is a mixture of venous and arterial blood and may be contaminated with interstitial or even intracellular fluid. Cystatin C is produced by all nucleated cells in the body (5) and enters the interstitium and, from there, the bloodstream. The concentrations of cystatin C have been comparable in most body fluids studied (e.g., blood, tears, milk, saliva, and . . . [Full Text of this Article]






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