Clinical Chemistry
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Clinical Chemistry 51: 1074-a-1076-a, 2005; 10.1373/clinchem.2004.045807
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(Clinical Chemistry. 2005;51:1074-1076.)
© 2005 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Detrimental Effect of Formaldehyde on Plasma RNA Detection

Grace T.Y. Chung1, Rossa W.K. Chiu1, K.C. Allen Chan1, Tze K. Lau2, Tse N. Leung2, Lin W. Chan2 and Y.M. Dennis Lo1,a

Departments of1 Chemical Pathology and2 Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China

aAddress correspondence to this author at: Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing St., Shatin, New Territories, Hong Kong Special Administrative Region, China. Fax 852-2194-6171; e-mail loym@cuhk.edu.hk.

The first 20% of the full text of this article appears below.


To the Editor:

Recent studies have shown that detection of fetal DNA or RNA in maternal plasma is useful for prenatal investigation of certain fetal genetic traits (1)(2) or pregnancy-associated complications (3)(4). Fetal DNA has been shown to amount to 3.4%–6.2% of the total DNA in maternal plasma (5). Thus, the reliability of circulating fetal nucleic acids analysis is dependent on the ability to sensitively and specifically detect and distinguish such fetal molecules from a background of maternal nucleic acids. Hence, methods that enable enrichment of the proportion of fetal nucleic acids in maternal plasma would, in theory, facilitate robust analysis of circulating fetal nucleic acids. Dhallan et al. (6) recently explored the use of formaldehyde for the enrichment of circulating fetal DNA. The authors reported marked increases in the proportion of fetal DNA in maternal blood samples preserved with formaldehyde. Although controversies exist regarding . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


Home page
 J. Clin. Pathol.Home page
E C W Hung, R W K Chiu, and Y M D Lo
Detection of circulating fetal nucleic acids: a review of methods and applications
J. Clin. Pathol., April 1, 2009; 62(4): 308 - 313.
[Abstract] [Full Text] [PDF]

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 Clin. Chem.Home page
Y. M. Dennis Lo and R. W. K. Chiu
Noninvasive Prenatal Diagnosis of Fetal Chromosomal Aneuploidies by Maternal Plasma Nucleic Acid Analysis
Clin. Chem., March 1, 2008; 54(3): 461 - 466.
[Abstract] [Full Text] [PDF]


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