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Clinical Chemistry 51: 1076-1077, 2005; 10.1373/clinchem.2005.048710
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(Clinical Chemistry. 2005;51:1076-1077.)
© 2005 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Paraprotein Interference in an Assay of Conjugated Bilirubin

Andrea Nauti1, Alessandra Barassi2,a, Giampaolo Merlini3 and Gian Vico Melzi d’Eril4

1 Laboratorio di Analisi, Ospedale di Circolo, Varese, Italy
2 Dipartimento di Scienze, Biomediche Sperimentali e Cliniche, Università degli Studi dell’Insubria, Varese, Italy
3 Laboratori di Biotecnologie, IRCCS Policlinico S. Matteo, Dipartimento di Biochimica, Università degli Studi di Pavia, Pavia, Italy
4 Dipartimento di Medicina, Chirurgia e Odontoiatria, Università degli Studi di Milano, Milan, Italy

aAddress correspondence to this author at: via Dunant 5, 21100 Varese, Italy. E-mail alessandra.barassi@tin.it.

The first 20% of the full text of this article appears below.


To the Editor:

Artifactually increased total bilirubin and artifactually low HDL have been described recently in a patient with a monoclonal IgM paraprotein (1). Similar interferences have already been described for serum samples containing paraproteins when tested for bilirubin [with a reagent from the same manufacturer (2)], phosphate(3)(4)(5)(6)(7), creatinine (8), calcium(9), urea nitrogen(10), iron (11), C-reactive protein, and antistreptolysin-O (12). Here we describe interference in the measurement of conjugated bilirubin by a different analyzer in sera from 3 patients (A, B, and C) with IgG-{kappa}–type myeloma. Conjugated bilirubin was initially measured with the Olympus AU2700 automated analyzer using the Olympus conjugated bilirubin assay. For patient A (40-year-old man), the reported conjugated bilirubin was 37.5 mg/L, total bilirubin was 2.0 mg/L . . . [Full Text of this Article]






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