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Clinical Chemistry 51: 1077-1078, 2005; 10.1373/clinchem.2004.045740
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(Clinical Chemistry. 2005;51:1077-1078.)
© 2005 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Paraprotein Interference in Automated Chemistry Analyzers

Chelsea A. Sheppard1,a, Robert C. Allen1,3, Garth E. Austin1,4, Andrew N. Young1,4, Maria A. Ribeiro2,4 and Corinne R. Fantz1

Departments of1 Pathology and Laboratory Medicine, and2 Hematology/Oncology, Emory University Hospital, Atlanta, GA
3 Grady Memorial Hospital, Atlanta, GA
4 Veterans Affairs Medical Center, Atlanta, GA

aAddress correspondence to this author at: Department of Pathology and Laboratory Medicine, Emory University Hospital, 1364 Clifton Road NE, Atlanta, GA 30322. E-mail csheppa@emory.edu.

The first 20% of the full text of this article appears below.


To the Editor:

We read with interest the Technical Brief by Smogorzewska et al. (1) describing an artificially increased total bilirubin in a patient with a monoclonal IgM paraprotein. Monoclonal paraproteins have been shown to artifactually influence several automated assays of different methodologies, including nephelometry, turbidometry, and immunologic assays, by forming precipitates during the assay procedure (2)(3)(4)(5)(6)(7). The total bilirubin assay on the Hitachi 917 automatic chemistry analyzer (Roche Diagnostics) has been reported to yield falsely increased bilirubin values as a result of paraprotein interference (1)(8).

Smogorzewska et al. (1) and Pantanowitz et al. (8) described this artifact as rare, but we have identified 6 patients at 2 hospitals with documented paraproteins who had falsely increased serum total bilirubin. Notably, . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


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[Abstract] [Full Text] [PDF]


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