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Letters to the Editor |
1 Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
2 Centro Universitário Feevale, Novo Hamburgo, Brazil
3 R&D DIAGNOSTICS Ltd., Papagos, Greece
4 New York State, Department of Health, Wadsworth Center, Albany, NY
5 Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
aAddress correspondence to this author at: Faculdade de Farmácia, UFRGS, Av. Ipiranga, 2752, Porto Alegre, RS, Brazil, 90610-000. Fax 55-51-33165434; e-mail scastro@adufrgs.ufrgs.br.
| The first 20% of the full text of this article appears below. |
To the Editor:
Fujimoto et al. (1) reported that the stability of galactose 1-phosphate in dried blood spots for neonatal screening was adversely affected by humidity and temperature, especially when low-value samples are evaluated. We extend these findings to glucose-6-phosphate dehydrogenase (G-6-PD; EC 1.1.1.49) activity, deficiency of which is by far the most common genetic disease worldwide (2) and accounts for more than one-half of the cases of severe jaundice among male newborns in Greece, China, and in Sephardic Jewish groups (3). Tests for G-6-PD deficiency are thus included in newborn screening programs in some regions.
We
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