Clinical Chemistry
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Clinical Chemistry 51: 1080-1081, 2005; 10.1373/clinchem.2005.048520
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(Clinical Chemistry. 2005;51:1080-1081.)
© 2005 American Association for Clinical Chemistry, Inc.


Letters to the Editor

Evaluation of Glucose-6-Phosphate Dehydrogenase Stability in Blood Samples under Different Collection and Storage Conditions

Simone M. Castro1,a, Raquel Weber1, Vivian Dadalt1, Vanessa F. Santos2, George J. Reclos3, Kenneth A. Pass4 and Roberto Giugliani5

1 Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
2 Centro Universitário Feevale, Novo Hamburgo, Brazil
3 R&D DIAGNOSTICS Ltd., Papagos, Greece
4 New York State, Department of Health, Wadsworth Center, Albany, NY
5 Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

aAddress correspondence to this author at: Faculdade de Farmácia, UFRGS, Av. Ipiranga, 2752, Porto Alegre, RS, Brazil, 90610-000. Fax 55-51-33165434; e-mail scastro@adufrgs.ufrgs.br.

The first 20% of the full text of this article appears below.


To the Editor:

Fujimoto et al. (1) reported that the stability of galactose 1-phosphate in dried blood spots for neonatal screening was adversely affected by humidity and temperature, especially when low-value samples are evaluated. We extend these findings to glucose-6-phosphate dehydrogenase (G-6-PD; EC 1.1.1.49) activity, deficiency of which is by far the most common genetic disease worldwide (2) and accounts for more than one-half of the cases of severe jaundice among male newborns in Greece, China, and in Sephardic Jewish groups (3). Tests for G-6-PD deficiency are thus included in newborn screening programs in some regions.

We . . . [Full Text of this Article]







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Copyright © 2005 by the American Association for Clinical Chemistry.