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Clinical Chemistry 51: 1302-1303, 2005; 10.1373/clinchem.2005.050187
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(Clinical Chemistry. 2005;51:1302-1303.)
© 2005 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Detection of Heavy Chain Disease by Capillary Zone Electrophoresis

Godelieve Mariën1, Gregor Verhoef2 and Xavier Bossuyt1,a

1 Laboratory Medicine, Immunology, and 2 Internal Medicine, Hematology, University Hospital Leuven, Leuven, Belgium

aAddress correspondence to this author at: Laboratory Medicine, University Hospital Leuven, Herestraat 49, B-3000 Leuven, Belgium. Fax 32-16-347931; e-mail Xavier.bossuyt@uz.kuleuven.ac.be.

The first 20% of the full text of this article appears below.


To the Editor:

Luraschi et al. (1) recently published the first report describing the use of capillary zone electrophoresis (CZE) coupled with immunosubtraction to detect and characterize low concentrations of free {gamma} heavy chains in serum. By contrast, we describe a case in which CZE failed to detect and characterize µ heavy chain disease.

A 90-year-old woman who complained of weight loss presented with progressive enlargement of the left parotid gland, splenomegaly, and palpable inguinal lymph node enlargements. A combined positron emission tomography/computed tomography whole body scan confirmed left parotid involvement as well as supra- and infradiaphragmatic involvement of the lymph nodes. Laboratory investigation showed hemoglobin, leukocyte count and differentiation, and a platelet count within the appropriate reference intervals. Serum lactate dehydrogenase was increased. The IgG concentration was 5.46 g/L, the . . . [Full Text of this Article]






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