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Clinical Chemistry 51: 1749-1750, 2005; 10.1373/clinchem.2005.051961
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(Clinical Chemistry. 2005;51:1749-1750.)
© 2005 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Increased Serum Concentrations of Soluble Receptor for Advanced Glycation Endproducts in Patients with Type 1 Diabetes

Marion Challier1, Sophie Jacqueminet2, Ouardia Benabdesselam1, André Grimaldi2 and Jean-Louis Beaudeux1,a

1 Fédération de Biochimie, and,
2 Service de Diabétologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France

aAddress correspondence to this author at: Fédération de Biochimie, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l’Hôpital, F75651 Paris Cedex 13, France. Fax 33-1-42-16-21-75; e-mail jean-louis.beaudeux@psl.aphp.fr.

The first 20% of the full text of this article appears below.

To the Editor:

The hyperglycemic state occurring in diabetes mellitus is responsible for formation and accumulation of advanced glycation endproducts (AGEs) that participate in the pathogenesis of vascular complications of diabetes mellitus (1). There is considerable interest in the receptors for AGEs (RAGE) found in many cell types, particularly those affected in diabetes. RAGE are members of the immunoglobulin family of cell surface molecules with a diverse repertoire of ligands. Interaction of AGEs with RAGE alters several cell functions through modulation of intracellular signaling, gene expression, and release of proinflammatory molecules and free radicals that contribute to the pathology of diabetic complications (2)(3). A soluble form of RAGE (sRAGE) can be measured in peripheral blood, which could result from the expression of a RAGE splice gene variant that encodes an amino-terminally truncated form of the receptor and/or from the cleavage of the native membranous receptor (4). This form may be released by several cell types, such as endothelial cells and circulating leukocytes. Because sRAGE is presumed to be a . . . [Full Text of this Article]




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Serum Levels of Soluble Form of Receptor for Advanced Glycation End Products (sRAGE) May Reflect Tissue RAGE Expression In Diabetes
Arterioscler. Thromb. Vasc. Biol., June 1, 2007; 27(6): e32 - e32.
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P. M. Humpert, S. Kopf, Z. Djuric, T. Wendt, M. Morcos, P. P. Nawroth, and A. Bierhaus
Plasma sRAGE Is Independently Associated With Urinary Albumin Excretion in Type 2 Diabetes
Diabetes Care, May 1, 2006; 29(5): 1111 - 1113.
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