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Clinical Chemistry 51: 1750-1751, 2005; 10.1373/clinchem.2005.053819
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(Clinical Chemistry. 2005;51:1750-1751.)
© 2005 American Association for Clinical Chemistry, Inc.

Letters to the Editor

High {gamma}-Glutamyltransferase (GGT) Activity in Human Breast Milk Confounds Interpretation of High Serum GGT Activity in a Nursing Infant with Liver Disease

Dorothy B. Colagiovanni1,a, Dennis J. Meyer1, Julie M. Wolf1, Karen Hart1, Elizabeth Abbott1 and Corrie Santos2

1 OSI Pharmaceuticals, Inc., Boulder, CO
2 University of Colorado at Denver, Health Sciences Center, Department of Geography, and Environmental Sciences Denver, CO

aAddress correspondence to this author at: OSI Pharmaceuticals, Inc., 2860 Wilderness Place, Boulder, CO 80301. Fax 303-665-3455; e-mail dotc@replidyne.com.

The first 20% of the full text of this article appears below.

To the Editor:

We are writing to reiterate to the medical community that {gamma}-glutamyltransferase (GGT) activity is high in human breast milk for at least 4 weeks postpartum (1)(2) and to suggest that GGT from milk may increase circulating GGT activity in breastfed newborns. An infant was diagnosed with biliary atresia and was surgically managed by a Roux-en-Y hepatoportojejunostomy. The subsequent persistence of high serum GGT activity in the circulation, despite a gradual decrease in the serum bilirubin concentration, prompted concern of an incomplete response to treatment. Because the infant was being breast fed, an . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
R. Iorio, A. Giannattasio, E. Lamberti, C. Della Corte, E. Nicastro, and M. I. Spagnuolo
Hyper-{gamma}-Glutamyltransferase Is Commonly Present in Non-Breast-Fed Infants with Biliary Atresia Successfully Treated with Portoenterostomy.
Clin. Chem., July 1, 2006; 52(7): 1430 - 1430.
[Full Text] [PDF]


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