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Clinical Chemistry 51: 1754-1755, 2005; 10.1373/clinchem.2005.055657
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(Clinical Chemistry. 2005;51:1754-1755.)
© 2005 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Serum Free Hemoglobin Concentrations in Healthy Individuals Are Related to Haptoglobin Type

Na Na1, Jin Ouyang1, Youri E.C. Taes2 and Joris R. Delanghe2,a

1 Department of Chemistry, Beijing Normal University, Beijing, People’s Republic of China
2 Laboratory Clinical Chemistry, Ghent University Hospital, Ghent, Belgium

aAddress correspondence to this author at: Laboratory Clinical Chemistry, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium. Fax 32-9-240-4985; e-mail joris.delanghe@Ugent.be.

The first 20% of the full text of this article appears below.

To the Editor:

Hemoglobin (Hb) is the major erythrocyte protein, and measurement of free Hb in serum can be used as a marker of hemolysis. Classically, cyanohemoglobin spectrometry and immunonephelometric methods have been used for assaying free Hb in serum (1)(2).

Hb metabolism partly occurs in tissue macrophages, which can engulf senescent erythrocytes (extravascular hemolysis) or take up Hb released from ruptured erythrocytes (intravascular hemolysis) and immature erythrocytes in the bone marrow. Because of the oxidative and toxic properties of the iron-containing heme in Hb, Hb is complexed by the plasma protein haptoglobin (Hp). Hp is involved in promoting the clearance of plasma Hb because Hp strongly binds free Hb and is depleted during increased hemolysis. Hp is a . . . [Full Text of this Article]






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