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Clinical Chemistry 52: 2170-2172, 2006; 10.1373/clinchem.2006.072884
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(Clinical Chemistry. 2006;52:2170-2172.)
© 2006 American Association for Clinical Chemistry, Inc.

Abstracts of Oak Ridge Posters

A Magnetic Immunochromatographic Strip Test for Detection of Human Papillomavirus 16 E6

Roger B. Peck1,a, Johannes Schweizer2, Bernhard H. Weigl1, Chamorro Somoza2, Jon Silver2, John W. Sellors1 and Peter S. Lu2

1 PATH, Seattle, Washington 98107;2 Arbor Vita Corp., Sunnyvale, California 94085;

aaddress correspondence to this author at: PATH, 1455 NW Leary Way, Seattle, WA 98107; fax 206-285-6619, e-mail rpeck@path.org)

The first 20% of the full text of this article appears below.

Cervical cancer kills 230 000 women annually. Low-resource regions of the world are disproportionately burdened with 80% of the cases. Efficient screening methods are the key to decreasing the death toll from this disease. High-risk human papillomavirus (HPV) types have been identified as the etiological agent for >99% of cervical cancers. Infection with HPV is ubiquitous and is often resolved by the host. High-risk HPV infections leading to cervical cancer require the production of both HPV E6 and E7 oncoproteins (1)(2)(3)(4)(5). Thus, an assay capable of detecting high-risk HPV E6 from cervical swab samples may have a high positive predictive value and may help to accurately identify women at increased risk of progression to cancer.

Internal studies have shown that cervical cancer cell lines produce ~1 ng of E6 per 1 000 000 cells (data not shown). Work is continuing to quantify E6 amounts in cervical cell samples from clients with cancer, high-grade lesions (cervical intraepithelial neoplasia 2/3), and low-grade lesions (cervical intraepithelial neoplasia 1). Protein determinations performed on provider-collected cervical swabs indicate . . . [Full Text of this Article]






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Copyright © 2006 by the American Association for Clinical Chemistry.