Clinical Chemistry
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Clinical Chemistry 52: 1625-1627, 2006; 10.1373/clinchem.2006.071696
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(Clinical Chemistry. 2006;52:1625-1627.)
© 2006 American Association for Clinical Chemistry, Inc.

Letters to the Editor

A Mannose-Binding Lectin-Defective Haplotype Is a Risk Factor for Gastric Cancer

Olga Scudiero1, Gerardo Nardone2, Daniela Omodei1, Fabiana Tatangelo3, Dino Franco Vitale4, Francesco Salvatore1,a and Giuseppe Castaldo1,5

1 Dipartimento di Biochimica, e Biotecnologie Mediche, Università degli Studi di Napoli, "Federico II", and, CEINGE-Biotecnologie, Avanzate e SEMM, Naples, Italy
2 Dipartimento di Medicina, Interna e Sperimentale, Unità di Gastroenterologia, Università degli Studi di Napoli, "Federico II", Naples, Italy
3 Istituto dei Tumori, "Fondazione Pascale", Naples, Italy
4 Fondazione Salvatore Maugeri, IRCCS, Istituto Scientifico di Telese Terme, Benevento, Italy
5 Facoltà di Scienze, Università del Molise, Campobasso, Italy

aAddress correspondence to this author at: Dipartimento di Biochimica e Biotecnologie Mediche, via S. Pansini 5, 80131 Naples, Italy. Fax 39 081 746 36 50; e-mail salvator@unina.it.

The first 20% of the full text of this article appears below.


To the Editor:

El-Omar et al. (1) reported that interleukin (IL)-1 gene cluster variants that enhance the production of IL-1ß (a powerful inhibitor of gastric acid secretion) increase the risk of gastric cancer in Helicobacter pylori (HP)-infected patients. IL-1ß production is down-regulated by mannose-binding lectin (MBL) (2), an acute-phase glycoprotein that has a high affinity for gram-negative lipopolysaccharide and exerts immunological activity (3)(4). Variants in the promoter, the 5'UTR, and exon 1 of the MBL2 gene reduce the synthesis and activity of MBL (5).

To assess the relationships between MBL2 gene variants and HP-related gastric cancer, we analyzed the whole coding region and the 5'UTR of the MBL2 gene in DNA extracted (QIAamp, Qiagen) from neoplastic cells embedded in paraffin sections (used for histological diagnosis) from 145 unrelated patients (90 males) affected by noncardia gastric cancer. Eighty-seven (60.0%) had intestinal-type; 47 (32.4%), diffuse-type; and 11 . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


Home page
 JNCI J Natl Cancer InstHome page
S. R. Pine, L. E. Mechanic, S. Ambs, E. D. Bowman, S. J. Chanock, C. Loffredo, P. G. Shields, and C. C. Harris
Lung Cancer Survival and Functional Polymorphisms in MBL2, an Innate-Immunity Gene
J Natl Cancer Inst, September 19, 2007; 99(18): 1401 - 1409.
[Abstract] [Full Text] [PDF]


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