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Clinical Chemistry 53: 152-153, 2007; 10.1373/clinchem.2006.074229
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(Clinical Chemistry. 2007;53:152-153.)
© 2007 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Detection of Monoclonal Proteins by Capillary Zone Electrophoresis: Comparison of 2 Multichannel Automated Systems

Xavier Bossuyta and Godelieve Mariën

Laboratory Medicine, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium

aAddress correspondence to this author at: Laboratory Medicine, Immunology, University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium. Fax 32-16-34-70-42; e-mail xavier.bossuyt@uz.kuleuven.be.

The first 20% of the full text of this article appears below.


To the Editor:

Capillary zone electrophoresis (CZE) is an alternative method for separation of serum proteins (1). Two dedicated and automated multichannel instruments are available, the Paragon 2000 (Beckman-Coulter) and the Capillarys (Sebia). The sensitivity and specificity of Paragon 2000 for detection of monoclonal proteins have been reported to be 95%(2)(3)(4) and 78%(4), respectively. The low reported specificity reflects the frequent occurrence of slight abnormalities in the electropherogram at the anodal part of the {gamma}-globulin fraction (fibrinogen region)(4).

Only 2 studies (5)(6) evaluated the Capillarys for detection of monoclonal proteins and reported a high sensitivity, and . . . [Full Text of this Article]






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Copyright © 2007 by the American Association for Clinical Chemistry.