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Clinical Chemistry 53: 989-990, 2007; 10.1373/clinchem.2007.085399
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(Clinical Chemistry. 2007;53:989-990.)
© 2007 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Detection of Unexpected Isoforms of Human Chorionic Gonadotropin by Qualitative Tests

Carlie S. Sigel and David G. Grenachea

University of North Carolina, School of Medicine, Department of Pathology and, Laboratory Medicine, Chapel Hill, NC

aAddress correspondence to this author at: CB#7525, University of North Carolina School of Medicine, Chapel Hill, NC 27599. Fax 919-966-9490; e-mail dgrenach@unch.unc.edu.

The first 20% of the full text of this article appears below.


To the Editor:

Human chorionic gonadotropin (CG) is a heterodimeric glycoprotein hormone composed of noncovalently associated {alpha} and ß subunits that are synthesized by trophoblastic tissue in pregnancy. Systemic modification and degradation of the intact CG molecule and subunits leads to molecular heterogeneity in the serum and urine (1). The ß subunit is a component of nicked CG (CGn), CG ß-subunit (CGß), nicked CG ß-subunit (CGßn), and CG ß-core fragment (CGßcf).

Qualitative urine testing for CG is employed in point-of-care and laboratory settings because it is a rapid and effective pregnancy screen. These tests typically detect 20 to 25 IU CG/L and reportedly detect pregnancies at 8 to 12 days after conception (1). Most qualitative test devices are chromatographic immunometric assays that use antibodies that recognize distinct epitopes on the {alpha} and ß subunits, enabling the detection of heterodimeric CG isoforms (CG and CGn). Recently, we . . . [Full Text of this Article]






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Copyright © 2007 by the American Association for Clinical Chemistry.