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Clinical Chemistry 54: 610-611, 2008; 10.1373/clinchem.2007.101881
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(Clinical Chemistry. 2008;54:610-611.)
© 2008 American Association for Clinical Chemistry, Inc.


Commentaries

Commentary

Alan T. Remaley

National Institutes of Health, Bethesda, MD.

Address correspondence to the author at: National Institutes of Health, Bldg. 10, Rm. 2C-433, 10 Center Dr, MSC 1508, Bethesda, MD, 20892-1508. Fax 301-402-1885; e-mail aremaley@nih.gov.

The first 20% of the full text of this article appears below.

Although apolipoprotein (apo)A-I and apoB are measured by many laboratories as an adjunct to HDL and LDL concentrations, respectively, lipoproteins contain numerous other proteins, some of which have a profound effect on lipoprotein metabolism. ApoE, for example, resides on both antiatherogenic HDL particles and on proatherogenic apoB-containing lipoproteins, thus confounding the usefulness of apoE as a cardiovascular risk marker in unfractionated samples. Nevertheless, apoE has many different roles in lipoprotein metabolism, some of which . . . [Full Text of this Article]







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