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Clinical Chemistry 54: 615-617, 2008; 10.1373/clinchem.2007.093005
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(Clinical Chemistry. 2008;54:615-617.)
© 2008 American Association for Clinical Chemistry, Inc.

Letters

Preanalytical Factors Affecting RIA Measurement of Plasma Kisspeptin

Radha Ramachandran1,2, Michael Patterson1, Kevin G. Murphy1, Waljit S. Dhillo1, Sejal Patel1, Anna Kazarian1, Mohammad A. Ghatei1 and Stephen R. Bloom1,a

1 Department of Metabolic Medicine, Imperial College London, Hammersmith Hospital, London, UK
2 Division of Clinical Chemistry, Hammersmith Hospitals NHS Trust, London, UK

aAddress correspondence to this author at: Department of Metabolic Medicine, Imperial College London, 6th Floor Commonwealth Building, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK, Fax +44 (0) 20 8383 3142, e-mail s.bloom@imperial.ac.uk

The first 20% of the full text of this article appears below.


To the Editor:

Kisspeptins are peptide products of the KiSS-1 metastasis-suppressor (KISS1) gene and the natural ligands of the G-protein–coupled receptor GPR54. KISS1 was initially investigated as an antimetastasis gene. More recent studies have demonstrated that the kisspeptins are potent stimulators of the hypothalamo-pituitary-gonadal axis. Mice and humans with defective kisspeptin signaling show hypogonadotrophic hypogonadism and impaired sexual development (1)(2).

Plasma kisspeptin concentrations are <2 pmol/L in men and nonpregnant women. KiSS-1 mRNA is highly expressed in the placenta, and plasma kisspeptin concentrations increase dramatically, to thousands of picomoles per liter, during pregnancy (3). In addition, plasma kisspeptin is increased in women with gestational trophoblastic tumors, thus raising the possibility of measuring plasma kisspeptin as a novel tumor marker (4). Previous studies that have measured plasma kisspeptin in women during pregnancy have found significantly different concentrations of circulating kisspeptin (3)(4) that may be attributable to differences . . . [Full Text of this Article]






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