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A Major Step Forward in the Routine Measurement of Serum Free Thyroid Hormones

Laboratory for Analytical Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Belgium

Address correspondence to the author at:, Harelbekestraat, 72, Gent, Belgium B-9000, E-mail linda.thienpont@ugent.be

The first 20% of the full text of this article appears below.

In the field of free thyroid hormone testing, methods based on equilibrium dialysis (ED) or ultrafiltration (UF) of serum, before direct measurement of the hormone concentration in the dialysate or ultrafiltrate, are accepted to be gold standards(1). These measurement procedures, however, physically isolate the free from the protein-bound hormone fractions and have been considered too technically demanding, inconvenient, and relatively expensive for routine clinical laboratory use(2)(3). Typically, such methods are better suited for use in reference laboratories(4).

In this issue of Clinical Chemistry, Yue et al. report on the application of an ED isotope dilution–liquid chromatography/tandem mass . . . [Full Text of this Article]