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Clinical Chemistry 54: 770, 2008; 10.1373/clinchem.2007.094177
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(Clinical Chemistry. 2008;54:770.)
© 2008 American Association for Clinical Chemistry, Inc.

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Quantifying Protein in Cerebrospinal Fluid and Urine: Success Achieved

Michael A. Pesce1

1 New York Presbyterian Hospital; Columbia University Medical Center; New York, NY.

aAddress correspondence to the author at: New York Presbyterian Hospital, Columbia-University Medical Center, 622 West 168th Street, CHS-2-224, New York, NY 10032-3720. E-mail map8@columbia.edu.

The first 20% of the full text of this article appears below.

Featured Article: Pesce MA, Strande CS. A new micromethod for determination of protein in cerebrospinal fluid and urine. Clin Chem 1973;11:1265–7.1

This paper described a dye-binding micromethod for measuring protein concentrations in cerebrospinal fluid and urine. The method involved coprecipitation of the proteins with a Ponceau S dye trichloroacetic acid solution, dissolving the protein precipitate in dilute sodium hydroxide, and measuring the absorbance at 560 nm. This method was rapid, easy to use, and required a specimen volume of 5–50 µL.

I began my career as a clinical chemist in 1971 in the pediatric microchemistry laboratory at Columbia Presbyterian Medical Center. This laboratory served the newborn, infant, and child population of Babies Hospital, . . . [Full Text of this Article]






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