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Clinical Chemistry 54: 929-930, 2008; 10.1373/clinchem.2007.100636
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(Clinical Chemistry. 2008;54:929-930.)
© 2008 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Analytical Quality of Calcitonin Determination and Its Effect on the Adequacy of Screening for Medullary Carcinoma of the Thyroid

Etienne Cavalier1,a, Agnès Carlisi1, Jean-Paul Chapelle1 and Pierre Delanaye2

Departments of1 Clinical Chemistry and 2 Nephrology and Hypertension, University Hospital of Liege, University of Liege, Belgium

aAddress correspondence to this author at: Service de Chimie Médicale, Centre Hospitalier Universitaire de Liège, Domaine du Sart-Tilman, B-4000 Liège, Belgique, Fax +32 4 3667691, e-mail etienne.cavalier@chu.ulg.ac.be

The first 20% of the full text of this article appears below.


To the Editor:

Calcitonin, a 32–amino acid calcium-lowering peptide secreted by the C cells (parafollicular cells) of the thyroid, is used as a marker for medullary carcinoma of the thyroid (MCT). However, calcitonin is not specific for MCT, because it is also secreted by other neoplasms, including breast cancer and small cell lung cancer.

Secretion of calcitonin is regulated primarily by the concentration of extracellular calcium, but can also be stimulated by gastrin. Although calcitonin concentrations are higher in men than in women and tend to decline with age, many laboratories use a cutoff value of 10 ng/L instead of a population-based reference interval. Prior studies have shown that basal calcitonin concentrations are below this threshold in a normal population(1. . . [Full Text of this Article]






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