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Clinical Chemistry 43: 550, 1997;
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(Clinical Chemistry. 1997;43:550.)
© 1997 American Association for Clinical Chemistry, Inc.

Book Reviews

Immunoassay. Eleftherios P. Diamandis and Theodore K. Christopoulos, eds. San Diego: Academic Press, 1996, 579 pp, Paperback. ISBN 0-12-214730-8

Dennis M. Bleile

Behring Diagnostics Inc., 3404 Yerba Buena Road, San Jose, CA 95135

This book meets the goal expressed in the Preface by the editors of being an educational aid in training new "immunodiagnostic specialists." However, I have some doubts about their claim that the book will be relevant for a decade. With the ingenuity already demonstrated in this field and the exponential expansion of technology, few books remain important for that duration.

In 24 chapters prepared by a total of 34 authors, the book reviews a wide range of topics concerning the theory and art of immunoassays. It presents the fundamentals of immunoassay, including the theoretical basis of immunoassay, immunochemistry, antibody production, and interpretation of immunoassay data. More recent developments are also included, such as antibody engineering and new assay configurations. Individual chapters are devoted to fluorescence, chemiluminescence, bioluminescence, and thin-film immunoassays.

One of the best chapters is "Interferences in Immunoassays" by James Miller and Stanley S. Levinson, which brings many critical issues into one concise chapter. Larry Kricka's chapter, "Simultaneous Multianalyte Immunoassays," is short but thought provoking. In the longest (59 pages) and one of the strongest chapters, Gyorgy Csako describes free hormone measurements, enlightening the reader in this rather complicated area and providing many valuable tables and illustrations. Daniel Chan's chapter addressing automation of immunoassays is based primarily on two of his books—one written in 1994 and the other in 1996. This chapter entices the reader to read Chan's books.

One shortcoming of this book is that many of its chapters appear to have been written in 1993 or 1994. The editors probably had no control over the delay between the preparation and publication of chapters, but in the rapidly changing field of immunodiagnostics, information contained in books may become dated in a short time.

I recommend this book as an important aid for newcomers to the field of immunoassay. For a more complete text, clinical chemists might wish to compare this book with "The Immunoassay Handbook," edited by David G. Wild (published in 1994), to evaluate the type of book that may best suit their needs.





This Article
Right arrow Extract Freely available
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
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Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via ISI Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bleile, D. M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Bleile, D. M.
Related Collections
Right arrow Clinical Immunology
Right arrow Proteomics and Protein Markers
Right arrow Drug Monitoring and Toxicology
Right arrow Endocrinology and Metabolism
Right arrow Automation and Analytical Techniques

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