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Clinical Chemistry, Vol 39, 561-577, Copyright © 1993 by American Association for Clinical Chemistry
MH Zweig and G Campbell
Clinical Pathology Department, Warren G. Magnuson Clinical Center, Bethesda, MD.
The clinical performance of a laboratory test can be described in terms of diagnostic accuracy, or the ability to correctly classify subjects into clinically relevant subgroups. Diagnostic accuracy refers to the quality of the information provided by the classification device and should be distinguished from the usefulness, or actual practical value, of the information. Receiver-operating characteristic (ROC) plots provide a pure index of accuracy by demonstrating the limits of a test's ability to discriminate between alternative states of health over the complete spectrum of operating conditions. Furthermore, ROC plots occupy a central or unifying position in the process of assessing and using diagnostic tools. Once the plot is generated, a user can readily go on to many other activities such as performing quantitative ROC analysis and comparisons of tests, using likelihood ratio to revise the probability of disease in individual subjects, selecting decision thresholds, using logistic-regression analysis, using discriminant- function analysis, or incorporating the tool into a clinical strategy by using decision analysis.
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 M. H. Olsen, T. W. Hansen, M. K. Christensen, F. Gustafsson, S. Rasmussen, K. Wachtell, H. Ibsen, C. Torp-Pedersen, and P. R. Hildebrandt N-terminal pro-brain natriuretic peptide, but not high sensitivity C-reactive protein, improves cardiovascular risk prediction in the general population Eur. Heart J., June 1, 2007; 28(11): 1374 - 1381. [Abstract] [Full Text] [PDF]
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 B. Harris, D. Bailey, S. Miles, E. Bailey, K. Rogers, P. Roach, P. Thomas, M. Hensley, and G. G. King Objective Analysis of Tomographic Ventilation-Perfusion Scintigraphy in Pulmonary Embolism Am. J. Respir. Crit. Care Med., June 1, 2007; 175(11): 1173 - 1180. [Abstract] [Full Text] [PDF]
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R. Sposto, W. B. London, and T. A. Alonzo Criteria for Optimizing Prognostic Risk Groups in Pediatric Cancer: Analysis of Data From the Children's Oncology Group J. Clin. Oncol., May 20, 2007; 25(15): 2070 - 2077. [Abstract] [Full Text] [PDF]
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 G. M. Gonzalez, C. Carter, and E. Blanes Bilingual Computerized Speech Recognition Screening for Depression Symptoms: Comparing Aural and Visual Methods Hispanic Journal of Behavioral Sciences, May 1, 2007; 29(2): 156 - 180. [Abstract] [PDF]
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R.-O. Casasnovas, N. Mounier, P. Brice, M. Divine, F. Morschhauser, J. Gabarre, J.-Y. Blay, L. Voillat, P. Lederlin, A. Stamatoullas, et al. Plasma Cytokine and Soluble Receptor Signature Predicts Outcome of Patients With Classical Hodgkin's Lymphoma: A Study From the Groupe d'Etude des Lymphomes de l'Adulte J. Clin. Oncol., May 1, 2007; 25(13): 1732 - 1740. [Abstract] [Full Text] [PDF]
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Y.-J. Zhang, H.-C. Wu, J. Shen, H. Ahsan, W. Y. Tsai, H.-I Yang, L.-Y. Wang, S.-Y. Chen, C.-J. Chen, and R. M. Santella Predicting Hepatocellular Carcinoma by Detection of Aberrant Promoter Methylation in Serum DNA Clin. Cancer Res., April 15, 2007; 13(8): 2378 - 2384. [Abstract] [Full Text] [PDF]
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K. Ohuchida, K. Mizumoto, J. Yu, H. Yamaguchi, H. Konomi, E. Nagai, K. Yamaguchi, M. Tsuneyoshi, and M. Tanaka S100A6 Is Increased in a Stepwise Manner during Pancreatic Carcinogenesis: Clinical Value of Expression Analysis in 98 Pancreatic Juice Samples Cancer Epidemiol. Biomarkers Prev., April 1, 2007; 16(4): 649 - 654. [Abstract] [Full Text] [PDF]
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D. Coenen, P. Verschueren, R. Westhovens, and X. Bossuyt Technical and Diagnostic Performance of 6 Assays for the Measurement of Citrullinated Protein/Peptide Antibodies in the Diagnosis of Rheumatoid Arthritis Clin. Chem., March 1, 2007; 53(3): 498 - 504. [Abstract] [Full Text] [PDF]
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M. Boscolo, M. Gobbo, W. Mantovani, M. Degani, M. Anselmi, G. B. Monteiro, S. Marocco, A. Angheben, M. Mistretta, M. Santacatterina, et al. Evaluation of an Indirect Immunofluorescence Assay for Strongyloidiasis as a Tool for Diagnosis and Follow-Up Clin. Vaccine Immunol., February 1, 2007; 14(2): 129 - 133. [Abstract] [Full Text] [PDF]
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