Editorials:

Elizabeth M. Petty and Anthony A. Killeen

BRCA1 Mutation Testing: Controversies and Challenges
Clin Chem 1997 43: 6-8. [Extract] [Full Text] [PDF]  

Verghese Mathew and Amir Lerman

Clinical Implications of a Sandwich Enzyme Immunoassay for Big Endothelin-1
Clin Chem 1997 43: 9-10. [Extract] [Full Text] [PDF]  

Frederick Van Lente

Methodology and Subspecialty Consolidation in the Clinical Laboratory
Clin Chem 1997 43: 11-12. [Extract] [Full Text] [PDF]  

Molecular Pathology and Genetics:

Seung Ho Hong, Woo Hyun Park, Chung Choo Lee, Jung Han Song, and Jin Q Kim

Association between genetic variations of apo AI-CIII-AIV cluster gene and hypertriglyceridemic subjects
Clin Chem 1997 43: 13-17. [Abstract] [Full Text] [PDF]  

Els Schollen, Petra Vandenberk, Jean-Jacques Cassiman, and Gert Matthijs

Development of reverse dot-blot system for screening of mitochondrial DNA mutations associated with Leber hereditary optic atrophy
Clin Chem 1997 43: 18-23. [Abstract] [Full Text] [PDF]  

Elizabeth M. Rohlfs, William G. Learning, Kenneth J. Friedman, Fergus J. Couch, Barbara L. Weber, and Lawrence M. Silverman

Direct detection of mutations in the breast and ovarian cancer susceptibility gene BRCA1 by PCR-mediated site-directed mutagenesis
Clin Chem 1997 43: 24-29. [Abstract] [Full Text] [PDF]  

Arseni Markoff, Alex Savov, Vladimir Vladimirov, Nadia Bogdanova, Ivo Kremensky, and Varban Ganev

Optimization of single-strand conformation polymorphism analysis in the presence of polyethylene glycol
Clin Chem 1997 43: 30-33. [Abstract] [Full Text] [PDF]  

Jean Riou, Christian Godart, Didier Hurtrel, Mireille Mathis, Catherine Bimet, Josiane Bardakdjian-Michau, Claude Préhu, Henri Wajcman, and Frédéric Galactéros

Cation-exchange HPLC evaluated for presumptive identification of hemoglobin variants
Clin Chem 1997 43: 34-39. [Abstract] [Full Text] [PDF]  

Antonio A. Reyes, Paola Carrera, Elena Cardillo, Luis Ugozzoli, Jimmie D. Lowery, Ching-I P. Lin, Matthew Go, Maurizio Ferrari, and R. Bruce Wallace

Ligase chain reaction assay for human mutations: the Sickle Cell by LCR assay
Clin Chem 1997 43: 40-44. [Abstract] [Full Text] [PDF]  

Enzymes and Protein Markers:

Christian Weilke, Thomas Brinkmann, and Knut Kleesiek

Determination of xylosyltransferase activity in serum with recombinant human bikunin as acceptor
Clin Chem 1997 43: 45-51. [Abstract] [Full Text] [PDF]  

Elizabeth M. Macy, Timothy E. Hayes, and Russell P. Tracy

Variability in the measurement of C-reactive protein in healthy subjects: implications for reference intervals and epidemiological applications
Clin Chem 1997 43: 52-58. [Abstract] [Full Text] [PDF]  

Lourdes Loidi, Anxo Vidal, Juan B. Zalvide, José L. Puente, Francisco Reyes, and Fernando Domínguez

Development of ELISA to estimate thymosin ₁, the N terminus of prothymosin , in human tumors
Clin Chem 1997 43: 59-63. [Abstract] [Full Text] [PDF]  

Endocrinology and Metabolism:

Philippe Aubin, Gaelle Le Brun, Florina Moldovan, Jean-Marie Villette, Christophe Créminon, Jacques Dumas, Laurence Homyrda, Hany Soliman, Michel Azizi, and Jean Fiet

Sandwich-type enzyme immunoassay for big endothelin-1 in plasma: concentrations in healthy human subjects unaffected by sex or posture
Clin Chem 1997 43: 64-70. [Abstract] [Full Text] [PDF]  

Haiqin Rong, Leonard J Deftos, Hong Ji, and Elisabet Bucht

Two-site immunofluorometric assay of intact salmon calcitonin with improved sensitivity
Clin Chem 1997 43: 71-75. [Abstract] [Full Text] [PDF]  

Peter Holownia, Elizabeth Bishop, David J. Newman, W. Gary John, and Christopher P. Price

Adaptation of latex-enhanced assay for percent glycohemoglobin to a Dade Dimension^® analyzer
Clin Chem 1997 43: 76-84. [Abstract] [Full Text] [PDF]  

Wolfgang Withold, Franz P. Armbruster, Markus Karmatschek, and Hans Reinauer

Bone sialoprotein in serum of patients with malignant bone diseases
Clin Chem 1997 43: 85-91. [Abstract] [Full Text] [PDF]  

Drug Monitoring and Toxicology:

André Scholer, Jörg Boecker, Ulf Engelmayer, Knut Feldmann, Dieter Hannak, Reinhard Kattermann, Michael Oellerich, Hannelore Raith, Harald Schlebusch, Heinrich Wieland, Dominique Willems, Jochen Jarausch, and Ingrid Domke

Comparability of a new turbidimetric digoxin test with other immunochemical tests and with HPLC—a multicenter evaluation
Clin Chem 1997 43: 92-99. [Abstract] [Full Text] [PDF]  

William E. Wingert

Lowering cutoffs for initial and confirmation testing for cocaine and marijuana: large-scale study of effects on the rates of drug-positive results
Clin Chem 1997 43: 100-103. [Abstract] [Full Text] [PDF]  

Launa J. Aspeslet, Donald F. LeGatt, Gerard Murphy, and Randall W. Yatscoff

Effect of assay methodology on pharmacokinetic differences between cyclosporine Neoral^® and Sandimmune® formulations
Clin Chem 1997 43: 104-108. [Abstract] [Full Text] [PDF]  

Automation and Analytical Techniques:

Hansa Thakkar, David J. Newman, Peter Holownia, Carol L. Davey, Chi-Chin Wang, Joseph Lloyd, Alan R. Craig, and Christopher P. Price

Development and validation of a particle-enhanced turbidimetric inhibition assay for urine albumin on the Dade aca^® analyzer
Clin Chem 1997 43: 109-113. [Abstract] [Full Text] [PDF]  

Bert G. Wolthers, Ido P. Kema, Marcel Volmer, Reinhard Wesemann, Jürgen Westermann, and Bernhard Manz

Evaluation of urinary metanephrine and normetanephrine enzyme immunoassay (ELISA) kits by comparison with isotope dilution mass spectrometry
Clin Chem 1997 43: 114-120. [Abstract] [Full Text] [PDF]  

Patrick C. D'Haese, Glen F. Van Landeghem, Ludwig V. Lamberts, Vera A. Bekaert, Iris Schrooten, and Marc E. De Broe

Measurement of strontium in serum, urine, bone, and soft tissues by Zeeman atomic absorption spectrometry
Clin Chem 1997 43: 121-128. [Abstract] [Full Text] [PDF]  

Lipids and Lipoproteins:

Petr E. Jira, Jan G. N. de Jong, Fokje S. M. Janssen-Zijlstra, Udo Wendel, and Ron A. Wevers

Pitfalls in measuring plasma cholesterol in the Smith–Lemli–Opitz syndrome
Clin Chem 1997 43: 129-133. [Abstract] [Full Text] [PDF]  

Laboratory Management:

George A. Smythe and Cathryn M. Drew

REPCAT: Desktop expert system for interpreting and validating laboratory data for pheochromocytoma diagnosis with the database application Omnis 7^TM
Clin Chem 1997 43: 134-140. [Abstract] [Full Text] [PDF]  

Uttam C. Garg, Zhi-Jie Zheng, Aaron R. Folsom, Yvonne S. Moyer, Michael Y. Tsai, Paul McGovern, and John H. Eckfeldt

Short-term and long-term variability of plasma homocysteine measurement
Clin Chem 1997 43: 141-145. [Abstract] [Full Text] [PDF]  

General Clinical Chemistry:

Brigitte M. Winklhofer-Roob, Martin A. van't Hof, and David H. Shmerling

Reference values for plasma concentrations of vitamin E and A and carotenoids in a Swiss population from infancy to adulthood, adjusted for seasonal influences
Clin Chem 1997 43: 146-153. [Abstract] [Full Text] [PDF]  

Winnie Lee, Susan M. Roberts, and Robert F. Labbe

Ascorbic acid determination with an automated enzymatic procedure
Clin Chem 1997 43: 154-157. [Abstract] [Full Text] [PDF]  

Andrew Hutchesson, Mary Anne Preece, George Gray, and Anne Green

Measurement of lactate in cerebrospinal fluid in investigation of inherited metabolic disease
Clin Chem 1997 43: 158-161. [Abstract] [Full Text] [PDF]  

Case Reports:

Caicai Wu and Margaret A. Kenny

A case of sulfhemoglobinemia and emergency measurement of sulfhemoglobin with an OSM3 CO-oximeter
Clin Chem 1997 43: 162-166. [Abstract] [Full Text] [PDF]  

MEETING REPORT:

Alan H. B. Wu and Edward W. Bermes, Jr.

Report of the Third Conference on Education in Clinical Chemistry
Clin Chem 1997 43: 167-173. [Extract] [Full Text] [PDF]  

History:

Donald S. Young, Mary Cregar Berwick, and Leonard Jarett

Evolution of the William Pepper Laboratory
Clin Chem 1997 43: 174-179. [Extract] [Full Text] [PDF]  

Technical Briefs:

Piergiorgio Zuccaro, Simona Pichini, Ilaria Altieri, Mirella Rosa, Manuela Pellegrini, and Roberta Pacifici

Interference of Nicotine Metabolites in Cotinine Determination by RIA
Clin Chem 1997 43: 180-181. [Extract] [Full Text] [PDF]  

Susanne Mohr, Paul Cullen, Roland Schmidt, Andrea Cignarella, and Gerd Assmann

Avoidance of False Positives in PCR-Based mRNA Differential Display During Investigation of Nonstandardized Tissues or Cells
Clin Chem 1997 43: 182-184. [Extract] [Full Text]  

Laurence M. Galanti

Specificity of Salivary Thiocyanate as Marker of Cigarette Smoking Is Not Affected by Alimentary Sources
Clin Chem 1997 43: 184-185. [Extract] [Full Text]  

Gregory S. Makowski and Sidney M. Hopfer

Measurement of Maternal Folate Status and Risk of Neural Tube Defects
Clin Chem 1997 43: 185-186. [Extract] [Full Text]  

Sandy Huey-Jen Hsu and Keh-Sung Tsai

Different Age-Related Trends of Bone and Nonbone Forms of Alkaline Phosphatase in Chinese Men and Women
Clin Chem 1997 43: 186-188. [Extract] [Full Text]  

Letters to the Editor:

Nobuhiro Yukawa, Takashi Suzuoka, Takeshi Saito, Alexander R. W. Forrest, Motoki Osawa, Sanae Takeichi, Jacques A. Brunelle, and Robert F. Moran

Data Processing in CO-Oximeters That Use Overdetermined Systems • A manufacturer replies:
Clin Chem 1997 43: 189-191. [Extract] [Full Text] [PDF]  

Mar Muñoz-Perez, Dolores Sarrion-Pelous, Juana Jimenez-Jimenez, Pilar Martinez-Montiel, and Miguel Gallego-Valdes

Chronic Increased Serum Lipase in a Patient with Suspected Pancreatic Adenocarcinoma
Clin Chem 1997 43: 191-193. [Extract] [Full Text]  

Toshiyuki Yamada and Takashi Miida

Serum Amyloid A Remains at Physiological Concentrations in Coronary Atherosclerosis
Clin Chem 1997 43: 193. [Extract] [Full Text]  

Jan Górski, Wim T. Hermens, Jacek Borawski, Michal Mysliwiec, and Jan F. C. Glatz

Increased Fatty Acid-Binding Protein Concentration in Plasma of Patients with Chronic Renal Failure
Clin Chem 1997 43: 193-195. [Extract] [Full Text]  

Mauro Panteghini, Roberto Bonora, and Franca Pagani

Automated Immunoassay of Cardiac Troponin I in Serum Evaluated
Clin Chem 1997 43: 195-196. [Extract] [Full Text]  

Book Reviews:

Anthony A. Killeen

Nucleic Acid Analysis: Principles and Bioapplications. Charles A. Dangler. New York: Wiley, 1996, 284 pp. Hardback $89.95. ISBN 0-471-10358-6.
Clin Chem 1997 43: 197. [Extract] [Full Text] [PDF]  

D. Robert Dufour

Clinical Diagnosis and Management by Laboratory Methods, 19th ed. J.B. Henry, ed. Philadelphia: W.B. Saunders, 1996, 1556 pp., $79.00. ISBN 0-7216-6030-4.
Clin Chem 1997 43: 197-198. [Extract] [Full Text]  

The Clinical Chemist:

Compiled by David E. Bruns, Editor
Clin Chem 1997 43: 199-201. [Extract] [Full Text]  

NACB:

Lawrence A. Kaplan

Introduction and Summary: 1996 NACB Standard of Laboratory Practice
Clin Chem 1997 43: 202-204. [Extract] [Full Text] [PDF]  

John M. Lorenz

Assessing fluid and electrolyte status in the newborn
Clin Chem 1997 43: 205-210. [Abstract] [Full Text] [PDF]  

Edward R. Ashwood

Standards of laboratory practice: evaluation of fetal lung maturity
Clin Chem 1997 43: 211-214. [Abstract] [Full Text] [PDF]  

Robert T. Brouillette and David H. Waxman

Evaluation of the newborn's blood gas status
Clin Chem 1997 43: 215-221. [Abstract] [Full Text] [PDF]  

Gideon Koren

Therapeutic drug monitoring principles in the neonate
Clin Chem 1997 43: 222-227. [Abstract] [Full Text] [PDF]  

Philip Rosenthal

Assessing liver function and hyperbilirubinemia in the newborn
Clin Chem 1997 43: 228-234. [Abstract] [Full Text] [PDF]  

Tai C. Kwong and Rita M. Ryan

Detection of intrauterine illicit drug exposure by newborn drug testing
Clin Chem 1997 43: 235-242. [Abstract] [Full Text] [PDF]  

Anne R. Synnes

Use of the laboratory in prediction of outcome in the high-risk newborn
Clin Chem 1997 43: 243-248. [Abstract] [Full Text] [PDF]  

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